Naslov
Ocular involvement in dry mouth patients : value of six ophthalmologic parameters

Autori
Alajbeg, Ivan ; Knezović, Igor ; Karlović, Dalibor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 9th Biennial Congress of the European Association of Oral Medicine ; u: Oral Diseases 14 (2008) (S1) 1-48 ; Poster Abstracts 14-43 ; / Baum, Bruce ; Scully, Crispian - : Blackwell Publishing, 2008

Skup
Biennial Congress of the European Association of Oral Medicine (19 ; 2008)

Mjesto i datum
Salzburg, Austrija, 18.09.2008. - 20.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
xerostomia; xerophthalmia; Schirmer's test; salivary gland biopsy; Rose-Bengal score

Sažetak
Purpose were to assess lachrymal and salivary function in patients with Sjogren’ s syndrome (SS) and non-SS dry mouth patients ; to assess the reliability of 6 different surveys related to dry eye in SS diagnosis. Study included 66 dry mouth patients (48 patients with SS, and 18 age and sex matched non-SS sicca controls). All participants were examined: unstimulated whole saliva (UWS), stimulated whole saliva (SWS), serology testing, labial gland biopsy (LGB). Six ophthalmologic parameters were measured: subjective questionnaire Ocular Surface Disease Index (OSDI), and objective tests: Schirmer-I and Schirmer -II tests, Tear Break-up Time (TBUT) test, Rose-Bengal (RB) and Lissamine-green (LG) scores. Differences between groups were analyzed using Mann Whitney U-test ; ROC curves were calculated for each ophthalmologic parameter’ s sensitivity and specificity ; Spearman’ s coefficient assessed correlations between OSDI and objective ocular tests. Statistical differences between groups were found in UWS, SWS, OSDI and ophthalmologic tests. Most significant differences between groups were observed in RB and LG scores. Within SS group, between subjects with positive and negative LGB findings, statistically significant differences were found for ophthalmologic tests, UWS and SWS. ROC curves showed sensitivity and specificity of ocular parameters in ascending order: TBUT (0.714) OSDI (0.740), Schirmer-I (0.780), Schirmer-II (0.802), LG (0.990) and RB (1.000). Highest correlations with OSDI were observed for RB and LG cores, whereas for Schirmer-I was the lowest. Study reveals the limited reliability of TBUT and Schirmer-I, and emphasizes vital dye staining as the test of choice in the Sjogren’ s syndrome differential diagnosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Dentalna medicina

Napomena
DOI: 10.1111/j.1601-0825.2008.01481.x

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