Naslov
Advanced glycated hemoglobin correlation to HbA1c and diabetic microangiopathy

Autori
Turk, Zdenka ; Mesić, Ranko ; Kovačević, Ivana ; Benko, Bojan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 17th International and 13th European Congress of Clinical Chemistry and laboratory Medicine ; u: Clinical Chemistry and Laboratory Medicine 37 (1999) (S) / Siest, Gerard - Berlin : Walter de Gruyter, 1999, S198-S198

Skup
International Congress of Clinical Chemistry and laboratory Medicine (17 ; 1999) ; European Congress of Clinical Chemistry and laboratory Medicine (13 ; 1999)

Mjesto i datum
Firenca, Italija, 06.06.1999. - 11.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
diabetes; hemoglobin; advanced glycation

Sažetak
The finding that AGEs are formed on hemoglobin opens a possibility to assess the parameter of advanced glycation. Our objective was to investigate the diagnostic usability of Hb-AGE and evaluate the relationship to diabetic complications. Hb-AGE and HbA1c were measured in 100 patients (38 had microangiopathy) with diabetes duration of 1-30 yr and mean age 47.3ą16 yr. Hb-AGE was quantified by the competitive ELISA using polyclonal anti-AGE-RNase-antibodies to detect AGE immunoreactivities of proteins precipitated in red cell hemolysate. Hb-AGE was analysed in three groups according to HbA1c: (i) HbA1c<7%, Hb-AGE=6.7ą1.1 U/mg ; (ii) HbA1c=7-10%, Hb-AGE=9.1ą1.7 U/mg ; (iii) HbA1c>10%, Hb- AGE=12.7ą2.2 U/mg. In the well-controlled subgroup (HbA1c<8%, n=34), HbA1c and Hb-AGE were less tightly correlated (r=0.37, p<0.001). However, in those with poor glycemic control (HbA1c>8%, n=66), the related Hb-AGE was 12.7ą2.1 U/mg Hb, yielding a more significant correlation (r=0.51, p<0.001). The mean level of Hb-AGE was not significantly different between diabetics with (9.43ą2.5) and without (9.6ą2.0) microangiopathy. Hb-AGE did not correlate with age (r=0.09, p=0.57), diabetes duration (r=0.05, p=0.72) or severity of microangiopathy. It seems that Hb-AGE represents only the metabolic status, equally in the subjects with and without diabetic microangiopathy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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