Naslov
Influence of Helicobacter pylori Infection on Chronic Atrophic Corpus and Antral Gastritis

Autori
Katičić, Miroslava ; Naumovski-Mihalić, Slavica ; Filipec-Kanižaj, Tajana ; Mrzljak, Anna ; Dominis, Mara ; Gašparov, Slavko ; Prskalo, Marija ; Tićak, Mirjana ; Škurla, Bruno

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Helicobacter / Graham, Y., David - Houston (TX) : Wiley-Blackwell, 2007, 401-402

Skup
XX International Workshop on Helicobacter and related bacteria in chronic digestive inflammation

Mjesto i datum
Istanbul, Turska, 20.09.2007. - 22.09.2007

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Chronic atrophic gastritis; Evolution

Sažetak
Background: Long-term outcome of atrophic body and antral gastritis has not yet been clearly defined. AIM: To investigate the effects of H. pylori eradication among patients with gastric (GU) and duodenal (DU) ulcers and non-ulcer dyspepsia (NUD), with corpus atrophic gastritis(CAG) or antral atrophic gastritis(AAG) and to clarify is it eradication the only condition responsible for histological improvement. Methods: A total of 119(F/M 48/71 ; age 36-97 ; mean 59, 2) patients with CAG (70GU ; 32DU ; 17NUD) and 116 (F/M 60/56 ; age 21-78 ; mean 64, 9) with AAG (31GU ; 65DU ; 20NUD) were follow-up for 1-10-years after treatment. Each patient underwent endoscopy with four biopsies at the beginning and at every control. Results: After first year 93(78%) CAG-patients and 88(76%) AAG-patients were HP-negative. After period of 1, 2, 3-5, and 6-10-years CAG progressively disappeared and histology becomes normal in 72, 78, 88 and 95% respectively ; as well as in AAG: in 89, 89, 95 and 100% respectively. In every observational period patients with remaining CAG were statistically much more HP-positive then those with normalised histology (35, 43, 17 and 50% respectively in comparison to 16, 8, 12 and 11% respectively). In AAG situation was different ; after first year all patients with or without remaining atrophic gastritis were 23% H. pylori-positive, and after 2, and 3-5-years all patients with remaining atrophic gastritis were HP-negative, and others were HP-positive in 20, 13 and 6% respectively. Conclusion: Both, corpus and antral atrophic gastritis, improved after HP-eradication. HP-eradication is responsible for AAG improvement, less for CAG.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA