Naslov
Use of non-invasive neuroradiological methods in research pf psychoactive drugs

Autori
Henigsberg, Neven ; Kovačić, Zrnka ; Kalember, Petra

Izvornik
Psychiatria Danubina (0353-5053) 19 (2007), 3; 234-237

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
psychiatry ; fMRI ; MR-spectroscopy ; BOLD-fMRI ; drug research ; drug developement

Sažetak
Non-invasive neuroradiological methods like magnetic resonance spectroscopy (MRS), functional magnetic resonance imaging (fMRI), blood oxygenation level dependent (BOLD-imaging) recently entered in to the areas of research in psychiatry, psychoactive drug developement, as well as in clinical practice. fMRI can identify the regions of the brain associated with various of functions, can monitor recovery progression and response to the treatment and MRS can be used to study brain chemistry and metabolism. BOLD-imaging provides an indirect indication of neuronal activity. Future developements of different neuroimaging techniques are promissing not only in surgical planning, functional assessment in brain tumor management, monitoring functional chages, but also in discovery of pathopsycholoy of psychiatric disorders and recognition of new pharmacological targets. Those techniques could be implemented in the process of drug discovery and indentification of biomarkeres which are clinicaly relevant for developement of candidate drugs. Furthermore, those techniques establish the bridge between preclinical and clinical studies and allow the drug research in human in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA