Naslov
Improved antitumor effect by combined treatment of propolis and chemotherapeutic drugs

Autori
Oršolić, Nada ; Horvat Knežević, Atika ; Benković, Vesna ; Bašić, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Apimondia, 2007 / - , 2007

Skup
International Apicultural Congress, Melbourne, Australia

Mjesto i datum
Melbourne, Australija, 09.09.2007. - 14.09.2007

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
chemotherapeutic drugs; propolis preparations; flavonoids; tumor; toxicity

Sažetak
Using a Swiss albino mouse model of Ehrlich ascites tumor (EAT), we investigated antitumor efficacy of two preparations of propolis (water and ethanolic extract) or quercetin, a compound of propolis, combined with chemotherapeutic drugs (Cisplatin and Doxorubicin). Egzamination was directed to suppression of tumor progression expressed as the percent increased life span. Propolis or quercetin were administrated ip to animals at doses of 50 mg kg-1 body weight for three consecutive days before tumor inoculation. Doxorubicin (20 mg kg-1) or cisplatin (10 mg kg-1) were given to mice two days after tumor cell inoculation. The results of log rank test between treated and control mice showed:WSDP, p=0.00291 ; WSDP + CIS, p=0.00781 ; WSDP + DOX, p=0.4998 ; EEP, p=0.00902 ; EEP + CIS, p=0.27603 ; EEP + DOX, p=0.22014 ; QU, p=0.27454 ; QU + CIS, p=0.72713 ; QU + DOX, p= 0.02667 ; CIS, p=0.00350 ; DOX, p= 0.2593. Combined treatment with test compounds and Cisplatin resulted in pozitive outcome (p=0, 00853 ; p=0, 00767 ; p=0, 02500) versus cisplatin alone, however combined treatment with doxorubicin was ineffective. Our findings indicate that WSDP, EEP, and quercetin significantly enhanced the antiproliferative and cytotoxic action of cisplatin and that propolis compounds may be usefully used for lowering the toxicity and other deteriorating activities chemotherapeutic drugs.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

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