Naslov
Human metabolic databases for drug development and drug interactions

Autori
Ciloy, Jose Martin ; Kitajima, Masato ; Sakamaki, Takako ; Pawlak, Jaroslaw ; Rendić, Slobodan Petar

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts from the 8th international ISSX meeting / - , 2007, 118-118

Skup
8th international ISSX meeting

Mjesto i datum
Sendai, Japan, 09.10.2007. - 12.10.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
human metabolic databases; drug development; drug interactions

Sažetak
Presented is the further step in development and use of the Human Metabolism Databases created for use in drug research and development as a part of ADME Database Project. The databases are providing the latest data on specific interactions for a given substance with Human Phase I Enzymes such as P450 (CYP), FMO, AKR, MAO, and AO ; Human Phase II Enzymes such as Esterases, UGT, GST, SULT ; and more than 235 Human Transporters including ABCs, OATPs, OCTs, OATs, SLCs. The databases are supported by chemical/metabolite structures as well as kinetic values found in the literature. The databases are available online (http://life-science.fqs.fujitsu.com/admedb_en), and completely searchable by keywords or chemical structures. Advanced searches are also available to support investigations studies on drug-drug interaction.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA