Naslov
Zagreb spontaneously circling rats – a possible novel model of movement disorder

Autori
Rebić, Veseljka ; Lacković, Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
39th International Danaube Syposium, Journal of Neural Transmission, 114 ; 2007 / Riederer, Peter ; Gerlach, Manfred - Beč : New York (NY) : Springer, 2007, CXVIII-CXVIII

Skup
39th International Danaube Syposium for Neurological Science and Continuing Education

Mjesto i datum
Würzburg, Njemačka, 02.06.2007. - 05.06.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
cyclic behaviour; movement disorders; striatum; dopamine

Sažetak
RATIONALE: Several studies reported spontaneous circling behavior in inbred rat strains, which was attributed to the dopaminergic dysfunction (Loscher et al., Neuroscience 74: 1996 ; 1135-42, Lessenich et al. Neuroscience107: 2001 ; 615-28). Here we present novel phenotype of unilateral spontaneous circling behavior found among inbred Wistar rats. OBJECTIVES: to describe behavioral pattern of affected rats, determine possible line of inheritance and to investigate behavioral response to drug administration. MATERIALS AND METHODS: Open filed, tail-hanging and swimming test were used to asses motor abnormalities before and after administration of following agents: bromocriptine (10 mg/kg, i.p.) ; trihexyphenidyl (1.5 mg/kg, i.p.) ; clozapine (10 mg/kg, i.p.) ; haloperidol (5 mg/kg, i.p.) and sulpirid (100 mg/kg, i.p.) in affected and matched control rats. For the mating experiment circling-circling and circling-normal rats were paired. RESULTS: Phenotype: Affected rats of both sex exhibit intensive unilateral circling with strong and permanent head distortion towards the side of rotation. Circling occurs spontaneously or as a response to stress. Symptoms emerge between 2.5 and 5.5 months of age. Inheritance: Only 2 out of 38 offspring developed phenotype behavior. Behavioral tests and pharmacology: Affected rats weren’ t able to swim. In open field rats exhibited normal locomotor activity interrupted with phases of circling. In tail-hanging test rats exhibited extensive rotations. Landing response was damaged. Only haloperidol and sulpirid had significant effect to behaviors observed: circling was completely abolished, landing response was normal, 85% of affected rats were able to swim. CONCLUSION: Phenotype of Zagreb spontaneously unilateral circling rats differs from ones previously reported. Line of inheritance remains unknown. First pharmacological tests indicate that circling may be associated with dopaminergic D2 receptors.

Izvorni jezik
Engleski

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