Naslov
The effect of radioprotective and chemoprotective drug (WR-2721) on toxicity of actaminophen in mice

Autori
Aleksić, Joško ; Vergles, Domagoj ; Čulo, Filip ;

Izvornik
Periodicum biologorum (0031-5362) 110 (2008), 1; 107-109

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
WR-2721; acetaminophen; AST; ALT
(WR-2721; acetaminophen)

Sažetak
Abstract Background and Purpose: It is known that WR-2721 WR-2721 – [S-2-(3-aminopropylamino)ethylposphorothioate] has radioprotective and chemoprotective effects on non-tumor tissues, and is now introduced into clinical tumor therapy protocols.We investigated whetherWR-2721 have a protective role in acute liver injury induced with acetaminophen (APAP). Material and Method: CBA/H Zgr inbred mice of both sexes aged 12– 16 weeks, weighing 20– 25 g were used. Mice were given phenobarbitone- sodium in drinking water during 7 days (300 mg/kg) in order to induce hepatic drug-metabolizing enzymes. Thereafter, mice were fasted overnight andWR-2721 was given i.p. (50, 100 or 200 mg/kg). After 15– 30 minutes they received acetaminophen (APAP ; Paracetamol) 200 mg/kg by gastric tube. Animals were allowed food 4 hours later. The mortality of mice was followed for 3 days and serum aminotransferase levels were determined 24 hours after APAP administration. Results: Survival of mice was prolonged after all doses ofWR-2721, but significantly only after the dose of 100 mg/kg of WR-2721. Similarly, the pretreatment of mice with 100 mg/kg of WR-2721 highly significantly reduced serum aspartate aminotransferase levels (AST, p<0. 0005) and serum alanine aminotransferase levels (ALT, p<0.005). The doses of 50 and 200 mg/kg of WR-2721 also reduced AST and ALT, but not significantly. Conclusions: These data showed that WR-2721 has definitive hepatoprotective effect which is significant in very restricted dose range.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA