Naslov
The influence of multiorgan dysfunction syndrome on Outcome of Patients with Infective Endocarditis:

Autori
Baršić, Bruno ; Igor Klinar1, Bojan Biočina2, Arijana Boras1, Dragan Lepur1, Boris Starčević3, Željko Sutlić2, Josip Vincelj3

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Respiracijski center 50 let prvega slovenskega oddelka intenzivne terapije

Urednik/ci
Muzlovič, Igor, Jereb, Matjaž ;

Izdavač
Klinika za infekcijske bolezni in vročinska stanja - UKC Ljubljana

Grad
Ljubljana

Godina
2007

Raspon stranica
73-82

ISBN
978-961-6442-21-3

Ključne riječi
endocarditis, MODS

Sažetak
Background: One-hundred-eight consecutive patients with endocarditis was evaluated to assess risk factors for early lethal outcome. Measurements and results: The following variables were retrieved from the medical records: a) general patient’ s characteristics such as age, gender, chronic diseases, previous heart disease ; b) clinical presentation (severe sepsis with multiple organ dysfunction and/or shock, respiratory failure requiring mechanical ventilation), duration of illness until the diagnosis of IE, duration of hospitalisation, duration of fever (>37.5º C) after the start of appropriate antimicrobial therapy, type of affected valve, localisation, specification of major and minor Duke criteria ; c) complications such as central nervous affection, cardiac failure, embolisations ; d) interventions ( type and duration of antimicrobial therapy, timing of appropriate antimicrobial therapy, need for mechanical ventilation, surgical procedure) ; e) in-hospital outcome. Twenty-seven of 108 patients died during hospitalisation. Univariate analysis identified severity of sepsis characterised by the presence of MODS and/or septic shock, respiratory failure requiring mechanical ventilation, development of cardiac failure, S. aureus infection, absence of vegetations and CNS complications as factors associated with increased risk of death. The multivariate forward stepwise logistic regression analysis identified respiratory failure needing mechanical ventilation (p=0, 0001) and cardiac failure (p=0.0388) as significant independent predictors of a fatal outcome.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA