Naslov
[Klinič ka dijagnoza u procjeni bolesti larinksa s posebnim osvrtom na tumore i prekancerozne lezije
(Clinical diagnosis in the assessment of laryngeal diseases with special reference to tumors and precancerous lesions)

Autori
Cikojević , Draško ; Glunč ić , Ivo ; Peš utić -Pisac, Valdi

Izvornik
Medica Jadertina (0351-0093) 32 (2002); 43-48

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
larinks; prekancerozna lezija; tumor; klinička dijagnoza; patohistološki nalaz
(larynx; precancerous lesions; tumors; clinical diagnosis; PHD)

Sažetak
A total of 129 patients with various laryngeal diseases were examined, with special reference to tumors and precancerous lesions. Clinical and pathohistological findings were compared to assess the accuracy of clinical examination in particular laryngeal diseases. As compared with pathohistologic examination, clinical diagnosis showed a sensivity of 84, 3%, specificity of 98, 3%, and accuracy of 90, 7%. The accuracy of clinical diagnosis was 59/60 (98, 3%) in group 1 (laryngeal tumors), 41/52 (78, 8%) in group 2 (precancerous lesions), and 17/17 (100%) in group 3 (polypus). The lowest accuarcy was recorded in patients with laryngeal leukoplakia and chronic laryngitis: 18/25 (72%) and 10/13 (76, 9%), respectively. According to study results, laryngeal leukoplakia and chronic laryngitis pose the greatest diagnostic problems, as it is frequently difficult to differentiate between precancerous and incipient malignant lesions, and whether progression of a leukoplakia alteration to a malignant process has already occurred. Optimal excision of a laryngeal lesion requires intraoperative awareness of the diagnosis. Pathohistological examination of frozen section may often prove inadequate for accurate intraoperative diagnosis of precancerous lesions due to the small amount of biopsy material available. Therefore, pathohistological examination of paraffin section represents the base of all radical therapy in laryngeal diseases.

Izvorni jezik
Hrvatski

Znanstvena područja
Kliničke medicinske znanosti

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