Pregled bibliografske jedinice broj: 345847
High performance mass spectrometry for compositional and structural analysis of human brain gangliosides
High performance mass spectrometry for compositional and structural analysis of human brain gangliosides // 1st Advanced Research Workshop on Applications of Mass Spectrometry in Life Safety, The NATO Science for Peace and Security Programme
Arad, 2007. (predavanje, nije recenziran, neobjavljeni rad, znanstveni)
CROSBI ID: 345847 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
High performance mass spectrometry for compositional and structural analysis of human brain gangliosides
Autori
Vukelić, Željka ; Kalanj-Bognar, Svjetlana ; Zamfir, Alina D.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni
Izvornik
1st Advanced Research Workshop on Applications of Mass Spectrometry in Life Safety, The NATO Science for Peace and Security Programme
/ - Arad, 2007
Skup
1st Advanced Research Workshop on Applications of Mass Spectrometry in Life Safety, The NATO Science for Peace and Security Programme
Mjesto i datum
Băile Herculane, Rumunjska, 23.09.2007. - 27.09.2007
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
detection and structural identification of gangliosides; advanced mass spectrometry approaches; biomarkers
Sažetak
Gangliosides, sialylated glycosphingolipids, are the most abundant in cells, particularly plasma-membranes, of the mammalian central nervous system. They participate in many vital cellular events such as cell-to-cell communication and signaling. In this contribution our results related to the following topics were presented. Human brain ganglioside composition shows regional, developmental, and ageing specificity, while characteristic changes of the normal pattern have been observed in various neuropathological conditions. Our studies of human brain gangliosides by modern ultra-sensitive mass spectrometric approaches complemented with conventional chromatographic and immunochemical methods documented that specific ganglioside patterns contain much larger number of individual species than previously reported. Advantages of these methodologies for accurate and reliable composition/structure and structure-function analysis of brain gangliosides in health and neurological diseases (brain tumors, Alzheimer’ s disease) were elaborated. Also, challenging aspects of ganglioside investigation as potential diagnostic biomarkers and/or therapeutic targets/agents were summarized.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
108-1081870-2415 - Strukturno-funkcionalna glikolipidomika moždanog razvitka i maligne alteracije (Vukelić, Željka, MZOS ) ( CroRIS)
108-1081870-1877 - Uloga membranskih lipida u moždanom razvitku, starenju i neurodegeneraciji (Kalanj-Bognar, Svjetlana, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
