Naslov
Nasal powder drug delivery

Autori
Filipović-Grčić, Jelena ; Hafner, Anita

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni

Knjiga
Pharmaceutical Manufacturing Handbook: Production and Processes

Urednik/ci
Gad, Shayne Cox

Izdavač
John Wiley & Sons

Grad
Singapur : London : München : Ženeva : Tokyo : Hong Kong : Taipei : Peking : Šangaj : Tianjin : Chennai

Godina
2008

Raspon stranica
651-681

ISBN
978-0-470-25958-0

Ključne riječi
Nasal powder, Drug delivery, Formulation, Polymers, Microspheres, Chitosan, Toxicological considerations

Sažetak
Nasal dry powder formulations ; Benefits associated with nasal powder drug delivery Residence time in the nasal cavity, drug concentration at the absorption site, formulation stability ; Drug powder or drug/polymer powder formulation for nasal drug delivery? Drug solubility, absorption, irritability, drug carrier (polymer) ; Powder properties affecting nasal deposition and drug delivery ; Deposition pattern, aerodynamic properties, particle distribution in the nose, particle size, shape, density, flow Polymers in nasal powder delivery system Hydrophilic polymers, functional groups, polymer molecular weight, cross-linking density, swelling ability, transport enhancing effect, bioadhesive properties, new generation mucoadhesive polymers Microspheres as nasal drug delivery devices Drug delivery system, microspheres, polymeric composition, polymer-drug interaction, mucociliary clearance, nasal absorption, bioavailability ; Preparation methods Spray-drying method, emulsification method, emulsion polymerization technique ; Microsphere characterization ; Particle size, morphology, drug content, swelling properties, bioadhesion, drug release profile ; Chitosan formulated spray-dried microspheres ; Chitosan molecular weight, conventional microspheres, composed microspheres, spray-drying parameters, particle size analysis, encapsulation efficiency, physical state of the drug, zeta-potential, tensile studies, swelling studies, in vitro drug release Toxicological considerations Local irritation, tissue damage, epithelial toxicity, ciliotoxicity, mucus turnover, reversible effects

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA