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Pregled bibliografske jedinice broj: 341307

The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma

Jaganjac, Morana; Poljak-Blaži, Marija; Žarković, Kamelija; Joerg Schaur, Rudolf; Žarković, Neven
The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma // Cancer letters, 260 (2008), 1-2; 180-186 doi:10.1016/j.canlet.2007.10.039 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 341307 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma

Autori
Jaganjac, Morana ; Poljak-Blaži, Marija ; Žarković, Kamelija ; Joerg Schaur, Rudolf ; Žarković, Neven

Izvornik
Cancer letters (0304-3835) 260 (2008), 1-2; 180-186

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
oxidative burst ; granulocytes ; Walker 256 carcinoma ; anti-cancer effects ; spontaneous tumour regression ; sephadex ; tumor-cell lysis ; polymorphonuclear leukocytes ; nonoxidative mechanisms ; human-neutrophils ; oxidative burst ; cancer-patients ; cytotoxicity ; therapy ; phagocytosis ; mice

Sažetak
We described before that oxidative burst of granulocytes is cytotoxic for melanoma B16F10 and for Walker 256 carcinoma (W256). Therefore, we assumed that granulocytes could also be important mechanism of the host defence against tumour. In current study we report massive granulocyte infiltration at the site of W256 transplanted in the hind limb of Sprague– Dawley associated with spontaneous tumour regression observed for 22/25 rats (87%). Peripheral blood granulocytes of these animals were highly cytotoxic for W256 cells cultured in vitro. After the tumour disappearance the inflammatory oxidative burst of the granulocytes ended. Distraction of granulocytes from the tumour by s.c. Sephadex injection decreased the incidence of the W256 regression to only 7/25 animals (30%). These results suggest that innate immunity based on immune competent granulocytes may be the cause of well known phenomenon of spontaneous regression of W256 carcinoma.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Žarković, Neven, MZOS ) ( CroRIS)
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Žarković, Kamelija, MZOS ) ( CroRIS)
198-0000000-3104 - Uloga neutrofila i oksidacijskog stresa u operacijama kolorektalnog karcinoma (Stipančić, Igor, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Profili:

Avatar Url Marija Poljak-Blaži (autor)

Avatar Url Kamelija Žarković (autor)

Avatar Url Neven Žarković (autor)

Avatar Url Morana Jaganjac (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Jaganjac, Morana; Poljak-Blaži, Marija; Žarković, Kamelija; Joerg Schaur, Rudolf; Žarković, Neven
The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma // Cancer letters, 260 (2008), 1-2; 180-186 doi:10.1016/j.canlet.2007.10.039 (međunarodna recenzija, članak, znanstveni)
Jaganjac, M., Poljak-Blaži, M., Žarković, K., Joerg Schaur, R. & Žarković, N. (2008) The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma. Cancer letters, 260 (1-2), 180-186 doi:10.1016/j.canlet.2007.10.039.
@article{article, author = {Jaganjac, Morana and Poljak-Bla\v{z}i, Marija and \v{Z}arkovi\'{c}, Kamelija and Joerg Schaur, Rudolf and \v{Z}arkovi\'{c}, Neven}, year = {2008}, pages = {180-186}, DOI = {10.1016/j.canlet.2007.10.039}, keywords = {oxidative burst, granulocytes, Walker 256 carcinoma, anti-cancer effects, spontaneous tumour regression, sephadex, tumor-cell lysis, polymorphonuclear leukocytes, nonoxidative mechanisms, human-neutrophils, oxidative burst, cancer-patients, cytotoxicity, therapy, phagocytosis, mice}, journal = {Cancer letters}, doi = {10.1016/j.canlet.2007.10.039}, volume = {260}, number = {1-2}, issn = {0304-3835}, title = {The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma}, keyword = {oxidative burst, granulocytes, Walker 256 carcinoma, anti-cancer effects, spontaneous tumour regression, sephadex, tumor-cell lysis, polymorphonuclear leukocytes, nonoxidative mechanisms, human-neutrophils, oxidative burst, cancer-patients, cytotoxicity, therapy, phagocytosis, mice} }
@article{article, author = {Jaganjac, Morana and Poljak-Bla\v{z}i, Marija and \v{Z}arkovi\'{c}, Kamelija and Joerg Schaur, Rudolf and \v{Z}arkovi\'{c}, Neven}, year = {2008}, pages = {180-186}, DOI = {10.1016/j.canlet.2007.10.039}, keywords = {oxidative burst, granulocytes, Walker 256 carcinoma, anti-cancer effects, spontaneous tumour regression, sephadex, tumor-cell lysis, polymorphonuclear leukocytes, nonoxidative mechanisms, human-neutrophils, oxidative burst, cancer-patients, cytotoxicity, therapy, phagocytosis, mice}, journal = {Cancer letters}, doi = {10.1016/j.canlet.2007.10.039}, volume = {260}, number = {1-2}, issn = {0304-3835}, title = {The involvement of granulocytes in spontaneous regression of Walker 256 carcinoma}, keyword = {oxidative burst, granulocytes, Walker 256 carcinoma, anti-cancer effects, spontaneous tumour regression, sephadex, tumor-cell lysis, polymorphonuclear leukocytes, nonoxidative mechanisms, human-neutrophils, oxidative burst, cancer-patients, cytotoxicity, therapy, phagocytosis, mice} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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