Naslov
I-131 total body burden in postsurgical patients with thyroid cancer

Autori
Medvedec, Mario ; Huić, Dražen ; Žuvić, Marijan ; Grošev, Darko ; Popović, Slavko ; Dodig, Damir ; Pavlinović, Željka

Izvornik
Radiology and oncology (1318-2099) 32 (1998), 3; 281-287

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
thyroid neoplasms-surgery; body burden; whole-body counting; radioiodine kinetics; internal dosimetry; iodine radioisotopes; radioioidne therapy

Sažetak
A whole body counter was used to study whole body retention of I-131 in order to estimate parameters of the retention curve, the total body absorbed dose, the correlation with the urine assay and the ratio of the ablationţtherapeutic over the diagnostic body burden. The retention in 48 patients after surgery for thyroid cancer was measured 2, 24, 48 and 72 h after the diagnostic administration of 82ą24 MBq and in 26/48 patients 72 h after the therapeutic administration of 4361ą216 MBq I-131. In 16 patients the activity of excreted urine was compared with in vivo measurements. In 44/48 patients the whole body retention curve was characterized by two exponential components, even in patients without evidence of radioiodine-concentrating thyroid tissue. The mean effective halfţlife was 10.9ą2.1 h and the total body absorbed dose 5.0ą2.2E-02 mGy/MBq. The urine assay overestimated whole body retention by a factor 2ţ5. The ratio of therapeutic versus diagnostic retention at 72 h was 0.82ą0.41 and significantly negative correlated with the retention at 72 h and the residence time of diagnostic activity, and with the time period between surgery and diagnostic study. Radioiodine kinetics in postsurgical patients with thyroid cancer is dependent on different variables. Accurate in vivo measurements of whole body retention provided some novel data about non-standard kinetics of radioiodine, and timing and dosage during I-131 ablation procedure.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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