Naslov
Cardiovascular Risk Factors in Chronic Renal Desease

Autori
Wagner, Jadranka ; Šerić, Vatroslav ; Babić-Ivančić, Vesna ; Milas-Ahić, Jasminka ; Kuveždić, Hrvoje

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
UROLOGY 70 (Supplment 3A), September 2007 / Klein, Eric A. - New York (NY) : Elsevier, 2007, 160-160

Skup
29th Congress of the Societe Internationale dUrologie

Mjesto i datum
Pariz, Francuska, 02.09.2007. - 06.09.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
chronic renal disease; atherosclerosis; cardiovascular risk factors

Sažetak
Introduction: Past scientific research has undeniably established that the most significant factor causing high mortality and high morbidity rate in patients with chronic renal disease is atherosclerosis. Although different risk factors have a role in atherosclerosis development the most important factors when considering haemodialysis obligated CRF patients were oxidative stress and dislipidemia. Methods: The aim of the study was to measure the effect of haemodialysis treatment on the general antioxidative status of serum with special consideration of the specific oxidizability of lipids and proteins. Indicators for oxidative/nonoxidative status of plasma were monitored at the beginnig and at the end of the haemodialysis. The study was conducted on a group of 59 patients (aged 20-75 ; 32 males and 27 females). These results were compared to control group of 59 people (aged 21-67, 20 males and 39 females). Results: A decrease in antioxidant status was accompanied by increased oxidizability of lipids as well as proteins during hemodialysis. Total antioxidant status was decreased from 1, 69_0, 23 to 1, 48_0, 27 mmol/L ; Homocistein from 28, 1_9, 6 to 20, 0 _ 11, 3 _mol/L ; C-reactive protein from 17, 4_ 26, 6 to 12, 2_ 14, 8 mg/L and Uric Acid from 370, 6_ 71, 2 to 108, 8_ 32, 6_mol/L while there was increase in Albumin concentration from 37, 7_3, 7 to 42, 9_ 5, 9 g/L ; Autoantibodies to oxidized LDL from 413, 1_ 332, 2 to 530, 8_ 371, 2 mU/ml ; HDL-C from 0, 86_0, 25 to 1, 02_0, 3 mmol/L ; LDL-C from 2, 57_0, 81 to 2, 9_0, 98 mmol/L. Conclusion: Our data demonstrate that the sensitiveness of serum lipids and proteins to oxidative modification is severely increased by haemodialysis treatment. Our investigation, also showed presence of the important atherosclerosis risk factors between CRD patients: dislipidemia, homocysteinemia, chronic inflammation and oxidative stress

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA