Naslov
Influence of biochemical parameters on prognosis in Non-Hodgkin's lymphoma - multivariate analysis with 32 variable on 217 patients

Autori
Planinc-Peraica, Ana ; Ostojić, Slobodanka ; Kardum-Skelin, Ika ; Radić-Krišto, Delfa ; Šušterčić, Dunja ; Jakšić, Ozren ; Minigo, Hrvoje ; Dominis, Marija ; Jakšić, Branimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
British Journal of Haematology / - , 1998

Skup
ISH-EHA Combined Haematology Congress

Mjesto i datum
Amsterdam, Nizozemska, 04.07.1998. - 08.07.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Non-Hodgkin lymphomas; clinical and laboratory parameters

Sažetak
Non-Hodgkin lymphomas (NHL) are characterised by considerable variability in course and prognosis. A number of clinical and laboratory parameters have been identified as prognostic factors. To investigate whether the simple biochemical parameters routinely taken at diagnosis are useful to identify uniform subsets according to prognosis uni- and multivariate analyses were done in 217 newly diagnosed NHL patients (pts). According to Kiel classification 142 (65%) pts had high grade malignancy NHL, and in 75 (35%) pts low grade malignancy. 76 (35%) pts had T-cell NHL, 139 (64%) B-cell NHL, wheras in 2 pts lymphoma cell origin was not possible to determine (or: 2 pts had non-B, non-T lymphoma ; or: 2 (1%) pts unclassified NHL). Median of age was 55 years, range 14 - 87. Male to female ratio was 1.1 (115/102). In an univariate analysis out of 32 parameters analysed, survival was associated with age (p = 0.0000), histological grade (p = 0.001), node immunology (p = 0.05), BM infiltration (p = 0.01), palpable liver (p = 0.009), stage (p = 0.01), ESR (p = 0.0008), Hb level (p = 0.0001), SGOT (p = 0.0004), LDH (p = 0.0007) ; total serum proteins (p = 0.01), serum albumins (p = 0.0002) and WBC (p = 0.04). All 32 parameters entered in Cox-proportional hazards analysis. The overall chi-square was 84.098. Summary of stepwise results disclosed age, ESR, histological grade, SGOT, BM infiltration, WBC and node immunology contributed independently to the model with respective approximate contribution of 28, 18, 11, 11, 10, 5 and 5 percent. We conclude that simple, routinely taken parameters are useful in predicting prognosis of NHL and contain considerable prognostic information. Among biochemical parameters only SGOT contributed independently to the model.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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