Naslov
Femoral head osteoarthritis – analysis of bone structure and turnover.

Autori
Staresinic, Mario ; Kusec, Vesna ; Sebecic, Bozidar ; Krpan, Dalibor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Calcified Tissue International / - , 2007

Skup
34th European Symposium on Calcified Tissues

Mjesto i datum
Kopenhagen, Danska, 05.05.2007. - 09.05.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
bone; osteoarthritis; histomorphometry

Sažetak
Increased bone remodeling of the subchondral bone occurs in the course of osteoarthritic destruction of bone and cartilage, also resulting in osteophytic growth. The aim of this study was investigation of static and dynamic histomorphometric parameters in bone specimens from the osteoarthritic femoral head obtained during hip replacement. Bone was analysed from areas of preserved articular cartilage, exposed subchondral bone and osteophyte from 23 patients (10 men, 13 women, 55-65 years) after double tetracycline labelling. Histomorphometric analysis was performed on undecalcified bone tissue sections stained with toluidine blue. Areas with bone cysts were excluded from analysis. Bone volume (BV/TV) was greater (p<0.04-0.001) in areas of preserved and damaged cartilage, trabecular thickness (TbTh) was greater (p<0.02) in preserved cartilage as compared to osteophytic bone. In women additionally, trabecular separation (TbS) was less (p<0.008-0.003) in areas of preserved and damaged cartilage, and osteoblast surface (ObS/BS) was greater (p<0.02) in preserved cartilage as compared to osteophytic bone. No statistically significant difference existed for histomorphometric parameters of bone resorption and dynamic parameters. Osteophytic bone was characterised by reduced bone structure as compared to other investigated areas of subchondral bone. The osteophyte trabecular network was reduced and less osteoblasts were additionally found in women. Bone turnover did not differ with regard to destruction degree of cartilage and bone in advanced osteoarthritis of the femoral head. The observed reduced bone structure in the osteophyte was probably related to its biomechanical traits, and more pronounced in women possibly due to postmenopausal osteoporosis. Bone turnover variations presumably occurring in the course of osteoarthritis are either absent in advanced stage or masked by variance due to histomorphometry and sample size.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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