Naslov
Correlation between Standard IHC Method and Herceptest in Detection of HER2/NEU Overexpression in Breast Cancer

Autori
Vrdoljak, Eduard ; Glavina Durdov, Merica ; Kuzmić Prusac, Ivana ; Tomić, Snježana ; Rozga, Ante ; Petrić Miše, Branka ; Alfirević, Darko ; Bezić, Joško ; Forempoher, Gea ; Karaman, Ivana ; Pešutić Pisac, Valdi ; Rakanović, Sadik.

Izvornik
Libri oncologici (0300-8142) 29 (2001), 1; 7-11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
HER2/neu; Trastuzumab; breast cancer; HerceptTest; c-erbB-2

Sažetak
Overexpression of the HER2 gene and its protein product could be confirmed using different methods in about 30% of breast cancers. It correlates with a worse prognosis and hormonal therapy resistance. On the other hand, a strong membranous expression of the HER2 oncoprotein presents an immunotherapeutical target for inhibiting a humanized antibody such as a commercially available drug Transtuzumab (Herceptin). To test the reproducibility of the pathohistological scoring we have analyzed HER2 protein expression in twenty-six cases of breast cancer by two comparable IHC methods. Based on the results of our study HER2 protein expression screening using the c-erbB-2 method could be used to find out potential candidates for HerceptTest evaluation . However, HerceptTest is a reliable method for HER2 protein scoring in the paraffin embedded tissue.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA