Naslov
Low dose clozapine improves dyskinesias in PD: A double blind study

Autori
Relja, Maja ; Koršić, Marta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Movement Disorders / Lees, Lang - New York (NY) : Lippincott Williams and Wilkins, 1998

Skup
5th International Congress of Parkinson`s Disease and Movement Disorders

Mjesto i datum
Sjedinjene Američke Države, 10.10.1998. - 14.10.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Clozapine; dyskinesias; PD

Sažetak
Clozapine possesses a relatively affinity for the D4 receptors. It has been reported that low dose of clozapine improves dyskinesias in chronic Parkinsonian patients. The aim of this study was to evaluate the efficacy and safety of clozapine in treatment of levodopa induced dyskinesias. 30 patients with idiopathic PD and dysabling dyskinesias (F/M 17/13, age range 41-72 years, the duration of disease 5-15 years, and the duration of levodopa treatment 4-15 years) we included in the double blind, placebo controlled crossover study with clozapine vrs placebo. PD disability was ela luated from motor part UPDRS complemented with dystonia score. In addition rigidity quantification was performrd using computerised dewice for the elbow joint. The evaluation was performed during levodopa test. Clozapine treated PD patiend showed clinically and statistically significant improvement of dyskinesias already one week after therapy was induced. PD motor disability score and/or rigidity measurment do not change significantly. Placebo treated patients did not show any clinically significant change from base line at any time point. This is the first double blind study that indicates that low dose clozapine may be potential benefit in management of disabling dystonias in PD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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