Naslov
Developmental reorganization of the human cerebral cortex

Autori
Kostović, Ivica ; Petanjek, Zdravko

Izvornik
Paediatria Croatica. Supplement (1330-724X) 51 (2007), Suppl 1; 93-98

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
PRETERM INFANT; CEREBRAL PATHWAYS; THALAMOCORTICAL AFFERENTS; SYNAPTOGENESIS; HISTOGENESIS

Sažetak
This paper reveals data on developmental reorganization of the human cortex. Three criteria were used to determine reorganization: (1) presence of transient cellular zones: ventricular (VZ), subventricular (SVZ), intermediate (IZ) zone, subplate (SP), cortical plate (CP) and marginal zone (MZ) ; (2) intensity of specific neuro developmental cellular events:proliferation, migration, differentiation, growth of axon and synaptogenesis ; (3) pattern of functional organization: (a) endogenous, transient circuitry and (b) permanent, sensory driven circuitry. First half of gestation is characterized by proliferation and migration. During the second half of gestation major axonal pathways grow through the intermediate zone and "wait" in the subplate. Initial synaptogenesis begins during third month of gestation and is related to the endogenous, spontaneous circuitry. In early preterm thalamocortical fibers relocate from the subplate(after 24th postconceptional weeks)and first evoked potentials may be recorded.The fundamental pattern is coexistence of endogenous and permanent, sensory driven circuitry. In neonatal brain synaptogenesis is main neurogenetic event and there is gradual disappearance of transient endogenous circuitry and transient cellular zones. The review support ideas of developmental "windows", selective vulnerability of specific transient cellular zones(subplate)and increased vulnerability of the human fetal and neonatal brain.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA