Naslov
The assessment of ovarian tumor angiogenesis: what does three-dimensional power Doppler add?

Autori
Kurjak, Asim ; Kupešić, Sanja ; Breyer, Branko ; Šparac, Vladimir ; Jukić, Stanko

Izvornik
Ultrasound in obstetrics & gynecology (0960-7692) 12 (1998), 2; 136-146

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
ultrasound; three dimensional imaging; fractal geometry; angiogenesis; tumor angiogenesis; blood vessel branching descriptors

Sažetak
It has been known for over 25 years that the development of new blood vessels is necessary to sustain the growth, invasion and metastasis of tumors. Angiogenesis is crucial for sustaining tumor growth, as it allows oxygenation and nutritient perfusion of the tumor as well as removal of waste products. Moreover, increased angiogensesis coincides with increased tumor cell entry into the circulation, and thus facilitates metastasis. Cancer cells activate the quiescent vasculature to produce new blood vessels via an 'angiogenetic switch', often during the premalignant stages of tumor development. Data suggestinf that control ofangiogenesis is separate from control of canncer cell proliferation raise the possibility that drugs inhibiting angiogenesis could offer a treatment that is complementary to traditional chemotherapy, which directly targets tumor cells. This exciting possibility has stimulated current research on tumor angiogenesis.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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