Naslov
CSF tau proteins in evaluation of patients with suspected dementia

Autori
Šimić, Goran ; Boban, Marina ; Šarac, Helena ; Grbić, Kristina ; Hof, Patrick ; Hamann, Christine ; Ackl, Nibal ; Bader, Benedikt ; Danek, Adrian

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
New trends in Alzheimer and Parkinson related disorders: ADPD 2007 (Current Contents)

Urednik/ci
Hanin, I ; Windisch M ; Poewe, W ; Fisher, A

Izdavač
Medimond International Proceedings

Grad
Bolonja

Godina
2007

Raspon stranica
239-243

ISBN
978-88-7587-405-6

Ključne riječi
cerebrospinal fluid, dementia, differential diagnosis, early diagnosis, phosphorylated epitopes, tau proteins, ELISA

Sažetak
Using commercially available ELISA kits, we evaluated the diagnostic value of CSF total tau protein (t-tau), tau phosphorylated at threonine 181 and serine 199 (p-tau181 and p-tau199) in early Alzheimer's disease (AD) versus healthy controls (HC) and other primary causes of dementia, such as frontotemporal dementia (FTD), vascular dementia (VaD) and dementia with Lewy-bodies (DLB). Mean CSF t-tau and CSF p-tau181 levels were significantly elevated in AD patients compared to FTD, VaD and HC. Discrimination between AD and DLB was maximized by using p-tau181 with a sensitivity of 91% and a specificity of 94%, whereas t-tau was optimal to separate AD from VaD with a sensitivity of 91% and specificity of 95%. P-tau199 showed low specificity of 20-30% in distinguishing AD from other groups when sensitivity was set at 85% or greater. We concluded that p-tau181 and t-tau represent useful biological markers for differentiating early AD from other causes of dementia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija

POVEZANOST RADA