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Pregled bibliografske jedinice broj: 335400

The role of tryptophan metabolism in iNOS transcription and nitric oxide production by chicken macrophage cells upon treatment with interferon gamma

Novak Kujundžić, Renata; Lowenthal, W. John
The role of tryptophan metabolism in iNOS transcription and nitric oxide production by chicken macrophage cells upon treatment with interferon gamma // Immunology letters, 115 (2008), 2; 153-159 doi:10.1016/j.imlet.2007.11.003 (međunarodna recenzija, članak, znanstveni)

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Naslov
The role of tryptophan metabolism in iNOS transcription and nitric oxide production by chicken macrophage cells upon treatment with interferon gamma

Autori
Novak Kujundžić, Renata ; Lowenthal, W. John

Izvornik
Immunology letters (0165-2478) 115 (2008), 2; 153-159

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Tryptophan metabolism ; Poly(ADP-ribose) polymerase ; Inducible nitric oxide synthase ; Chicken macrophage

Sažetak
The influence of de novo synthesis of nicotinamide adenine dinucleotide (NAD) through the kynurenine (KYN) pathway of tryptophan (TRP) degradation on gene transcription of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in chicken interferon gamma (ChIFN-γ )-stimulated and non-stimulated chicken macrophage cell line HD11 was investigated. Interferon gamma up regulation of iNOS transcription and NO production was dependent on an undisturbed flow through the KYN pathway. Inhibition of indoleamine-2, 3-dioxygenase, the rate-limiting enzyme of TRP catabolism, by 1-methyl-l-tryptophan (1-mTRP) down regulated both iNOS gene transcription and NO production. Addition of KYN to 1-mTRP-treated, ChIFN-γ -stimulated macrophages circumvented the down regulation of iNOS transcription and NO production. Inhibition of poly(ADP-ribose) polymerase (PARP), a nuclear enzyme involved in DNA repair, replication and transcription, which cleaves NAD into nicotinamide and ADP-ribose, down regulated iNOS gene transcription and NO production in ChIFN-γ -stimulated HD11 cells. Our results suggest that prevention of NAD depletion in HD11 cells by ChIFN-γ -mediated induction of IDO facilitates iNOS transcription and NO production. This effect is most likely a result of PARP1 automodification in the presence of NAD, known to facilitate transcription by changing chromatin structure and to allow NFκ B binding to iNOS promoter which is hindered by direct protein– protein interaction between NFκ B and unmodified PARP1.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982464-2511 - Epigenetičke i imunomodulatorne promjene u zloćudnim tumorima glave i vrata (Gall-Trošelj, Koraljka, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Renata Novak Kujundžić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Novak Kujundžić, Renata; Lowenthal, W. John
The role of tryptophan metabolism in iNOS transcription and nitric oxide production by chicken macrophage cells upon treatment with interferon gamma // Immunology letters, 115 (2008), 2; 153-159 doi:10.1016/j.imlet.2007.11.003 (međunarodna recenzija, članak, znanstveni)
Novak Kujundžić, R. & Lowenthal, W. (2008) The role of tryptophan metabolism in iNOS transcription and nitric oxide production by chicken macrophage cells upon treatment with interferon gamma. Immunology letters, 115 (2), 153-159 doi:10.1016/j.imlet.2007.11.003.
@article{article, author = {Novak Kujund\v{z}i\'{c}, Renata and Lowenthal, W. John}, year = {2008}, pages = {153-159}, DOI = {10.1016/j.imlet.2007.11.003}, keywords = {Tryptophan metabolism, Poly(ADP-ribose) polymerase, Inducible nitric oxide synthase, Chicken macrophage}, journal = {Immunology letters}, doi = {10.1016/j.imlet.2007.11.003}, volume = {115}, number = {2}, issn = {0165-2478}, title = {The role of tryptophan metabolism in iNOS transcription and nitric oxide production by chicken macrophage cells upon treatment with interferon gamma}, keyword = {Tryptophan metabolism, Poly(ADP-ribose) polymerase, Inducible nitric oxide synthase, Chicken macrophage} }
@article{article, author = {Novak Kujund\v{z}i\'{c}, Renata and Lowenthal, W. John}, year = {2008}, pages = {153-159}, DOI = {10.1016/j.imlet.2007.11.003}, keywords = {Tryptophan metabolism, Poly(ADP-ribose) polymerase, Inducible nitric oxide synthase, Chicken macrophage}, journal = {Immunology letters}, doi = {10.1016/j.imlet.2007.11.003}, volume = {115}, number = {2}, issn = {0165-2478}, title = {The role of tryptophan metabolism in iNOS transcription and nitric oxide production by chicken macrophage cells upon treatment with interferon gamma}, keyword = {Tryptophan metabolism, Poly(ADP-ribose) polymerase, Inducible nitric oxide synthase, Chicken macrophage} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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