Pregled bibliografske jedinice broj: 335397
Is renal erythropoietin secretion consequence of local hypoxia coupled with local suppression of angiogenesis?
Is renal erythropoietin secretion consequence of local hypoxia coupled with local suppression of angiogenesis? // Bioscience hypotheses, 2 (2009), 1; 50-51 (međunarodna recenzija, kratko priopcenje, znanstveni)
CROSBI ID: 335397 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Is renal erythropoietin secretion consequence of local hypoxia coupled with local suppression of angiogenesis?
Autori
Kurbel, Beatrica ; Kurbel, Sven
Izvornik
Bioscience hypotheses (1756-2392) 2
(2009), 1;
50-51
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni
Ključne riječi
VEGF; angiogenesis; erythropoietin; kidney medulla; urine concentration; hypoxia
Sažetak
It has recently been reported that angiogenesis is suppressed in the normal kidney tissue by the local production of ineffective VEGF165b (Schumacher VA et al. J Am Soc Nephrol 2007 ; 18:719-29). Due to restricted angiogenesis in normal kidney tissue, it seems that the chronically hypoxic kidney medulla might have been the reason that made kidneys the main source of erythropoietin secretion, as a rescue mode that increases local oxygen delivery. Cells in any hypoxic part of the kidney interstitial space, surrounded by capillaries with oxygen depleted blood that returns from medulla, are probably hypoxic enough to secrete erythropoietin.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
219-2192382-2009 - Procjena učinaka višesatne abdominalne kirurgije na perfuziju tankog crijeva (Dmitrović, Branko, MZOS ) ( CroRIS)
219-2192382-2386 - Razvoj modela funkcije cirkulacijskog sustava ovisnog o arterijskoj elastičnosti (Marić, Svjetlana, MZOS ) ( CroRIS)
Ustanove:
Klinički bolnički centar Zagreb,
Medicinski fakultet, Osijek
