Naslov
Is sympathetic activation by stressful memories linked to the occurrence of hypertension and metabolic syndrome?

Autori
Kurbel, Sven

Izvornik
Bioscience hypotheses (1756-2392) 1 (2008), 4; 179-184

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hypertension; metabolic syndrome; stress; memory; psychogenic

Sažetak
Large clinical studies report that patients with Alzheimer's disease normalize previously elevated blood pressure, while in previously hypertensive, elderly persons, an unexpected minority of hypotensive elderly patients with cognitive decline has been found. A possible interpretation is that both group of patients instead of having cognition problems due to arterial hypotension, might have become hypotensive due to reduced cognition that reduced their burden of stressful memories. Metabolic syndrome and/or hypertension are linked to the posttraumatic stress disorder, in noise exposure, occupational stress and material hardship. Here proposed concept is that memory induced stress reactions increase the resting sympathetic tone, vascular resistance, secretion of renin and contrainsulary hormones. Hyperglycemia stimulates basal insulin secretion, leading to diabetes, when insulin effects become outweighed by contrainsulary hormones. This might explain how is it possible that blocking of sympathetic activity and renin-angiotensin system prolongs human life, despite their importance in maintaining circulatory homeostasis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA