Naslov
Comparison of hormonal and metabolic markers after a high-fat, Western meal compared with a low-fat, high-fiber meal in women with polycystic ovary syndrome

Autori
Katcher, H. ; Kunselman, A. ; Dmitrović, Romana ; Demers, L. ; Gnatuk, K. ; Kris-Etherton, P. ; Legro, R.

Izvornik
Fertility and Sterility (0015-0282) 91 (2009), 4; 1175-1182

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hormones; metabolic markers; diat; PCOS

Sažetak
Objective: To determine the effect of meal composition on postprandial T levels in women with polycystic ovary syndrome (PCOS). Design: Randomized, crossover design. Setting: Academic research center. Patient(s): Fifteen women with PCOS. Intervention(s): We evaluated changes in T, sex hormone binding globulin (SHBG), DHEAS, cortisol, glucose, and insulin for 6 hours after a high-fat, Western meal (HIFAT) (62% fat, 24% carbohydrate, 1 g fiber) and an isocaloric low-fat, high-fiber meal (HIFIB) (6% fat, 81% carbohydrate, 27 g fiber). Main Outcome Measure(s): Change in T levels. Result(s): Testosterone decreased 27% within 2 hours after both meals. However, T remained below premeal values for 4 hours after the HIFIB meal and 6 hours after the HIFAT meal. Insulin was twofold higher for 2 hours after the HIFIB meal compared with the HIFAT meal. Glucose was higher for 1 hour after the HIFIB meal compared with the HIFAT meal. DHEAS decreased 8%-10% within 2-3 hours after both meals, then increased during the remainder of the study period. Cortisol decreased during the 6-hour period after both meals. CONCLUSIONS: Diet plays a role in the regulation of T levels in women with PCOS. Further studies are needed to determine the role of diet composition in the treatment of PCOS.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA