Naslov
Nitric oxide synthase in the hypothalamus of alloxan-diabetic rats.

Autori
Šalković-Petrišić, Melita ; Bicknell, John R

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Neuroscience. 1998 Forum of European Neuroscience / Everitt, Barry J - Cambridge : Wiley-Blackwell, 1998, Iv-iv

Skup
1998 Forum of European neuroscience

Mjesto i datum
Berlin, Njemačka, 27.06.1998. - 01.07.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
experimental diabetes; central nervous system; nitric oxide synthase

Sažetak
Alterations in neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) mediated transmission in diabetic animals have already been described in the peripherla nervous system, but no data have been reported fot the central nervous system. We have investigated the expression of n NOS mRNA in paraventricular (PARVN), periventricular (PERVN) and supraoptic (SON) hypothalamic nuclei of alloxan-diabetic rats using in situ hybridization with 35D labelled synthetic oligonucleotides. The expression of nNOS mRNA was greatly increased in the magnocellular part of PARVN and in SON of 1 week (+ 118% and +79%, p<0.05) and 4 week (+92% and +78%, py0.05) alloxan-diabetic animals, respectively. Our results suggest that elevated hypothalamic NO production and neurotoxicity may underlie brain pathologies observed in diabetes mellitus.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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