Naslov
Multidose activated charocoal in the treatment of carbamazepine overdose with seizures: a case report

Autori
Miše, Stjepan ; Jukić, Ivana ; Tonkić, Ante ; Titlić, Marina

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 56 (2005), 4; 333-338

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
intoxication; myoclonic seizures; poisoning; suicide

Sažetak
Serious complications after carbamazepine poisoning, such as coma, seizures, respiratory failure, cardiac conduction abnormalities, and death are more likely with serum levels greater than 170 umol/l. We report a case of a single massive carbamazepine overdose in a 19-year-old male, following attempted suicide, without prior history of seizure disorder. On admission, three hours after ingestion, serum carbamazepine concentration was 179 umol/l and Glasgow Coma Scale scores 6. The patient was intubated and treated with multiple doses of activated charcoal for 48 hours. Twelve hours after ingestion, two repeated generalised myoclonic seizures were noted when serum carbamazepine levels peaked at 181 umol/l, and were successfully treated with diazepam. Carbamazepine serum level fell within the therapeutic range 63 hours after ingestion and the patient was discharged without any long-term sequelae. As there is noantidote for carbamaepine poisoning, supportive treatment remains the only, but usually potent option.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA