Pregled bibliografske jedinice broj: 333657
Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis, have microbial origins
Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis, have microbial origins // Abstarct book / Carmen Buchrieser et al. (ur.).
Pariz: Institut Pasteur, Paris, France, 2008. str. 162 (P97)-162 (P97) (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 333657 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis, have microbial origins
Autori
Starcevic, Antonio ; Akthar, Shamima ; Dunlap, C. Walter ; Shick, J. Malcolm ; Hranueli, Daslav ; Cullum, John ; Long, F. Paul
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstarct book
/ Carmen Buchrieser et al. - Pariz : Institut Pasteur, Paris, France, 2008, 162 (P97)-162 (P97)
Skup
Genomes 2008: Functional Genomics of Microorganisms
Mjesto i datum
Pariz, Francuska, 08.04.2008. - 11.04.2008
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Shikimic acid pathway; Cnidaria; Nematostella vectensis; basal Metazoa; symbiosis; Tenacibaculum
Sažetak
The shikimic acid pathway is responsible for the biosynthesis of many aromatic compounds by a broad range of organisms, including bacteria, fungi, plants and some protozoans. Animals are considered to lack this pathway as evinced by their dietary requirement for shikimate-derived, aromatic amino acids. We challenge the universality of this traditional view in this first report of genes encoding enzymes for the shikimate pathway in an animal, the starlet sea anemone Nematostella vectensis. Molecular evidence establishes, for the first time, horizontal transfer of ancestral genes of the shikimic acid pathway into the N. vectensis genome from both bacterial and eukaryotic (dinoflagellate) donors. Additional bioinformatic analysis reveals four additional genes encoding enzymes of the shikimic acid pathway, raising speculation for the existence of a previously unsuspected bacterial symbiont. These results provide a complementary view for the biogenesis of shikimate-related metabolites in marine Cnidaria as a “ shared metabolic adaptation” between the partners. The results could also have wider implications for future development of the shikimic acid pathway as a ‘ druggable’ target in lead discovery for new antibiotics and for the treatment of parasitic infections including malaria.
Izvorni jezik
Engleski
Znanstvena područja
Biotehnologija
POVEZANOST RADA
Projekti:
0982560
058-0000000-3475 - Generiranje potencijalnih lijekova u uvjetima in silico (Hranueli/Jurica Žučko, Daslav, MZOS ) ( CroRIS)
Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb
