Pregled bibliografske jedinice broj: 333517
Glycotoxines, Carbonyl Stress and Relevance to Diabetes and its Complications
Glycotoxines, Carbonyl Stress and Relevance to Diabetes and its Complications // Physiological research, 59 (2010), 2; 147-156 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 333517 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Glycotoxines, Carbonyl Stress and Relevance to Diabetes and its Complications
Autori
Turk, Zdenka
Izvornik
Physiological research (0862-8408) 59
(2010), 2;
147-156
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
diabetes; carbonyl stress; methylglyoxal; glyoxal and 3-deoxyglucosone
Sažetak
A large body of evidence has implicated reactive carbonyl compounds as glycotoxic mediators of carbonyl stress. This review is focused on the physiopathologic effects of alpha-dicarbonyls in diabetes and related complications, summarizing the state-of-the-art on the endogenously produced carbonyls: methylglyoxal, glyoxal and 3-deoxyglucosone, formed as glycolytic intermediates during metabolic conversion of glucose, via Maillard reaction by degradation of glycated proteins, and during lipid peroxidation process. Their participation in the advanced glycation process and detrimental effects on vascular tissue are discussed. In addition, the analytical methods for their detection and measurement are described.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
045-0000000-0165 - GLIKOTOKSINI U ŠEĆERNOJ BOLESTI I KRONIČNIM KOMPLIKACIJAMA (Turk, Zdenka, MZOS ) ( CroRIS)
Ustanove:
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac
Profili:
Zdenka Turk
(autor)
