Naslov
Preconcentration of the lipid-lowering drug lovastatin at a hanging mercury drop electrode surface

Autori
Nigović, Biljana ; Pavković, Iva

Izvornik
Journal of Analytical Chemistry (1061-9348) 64 (2009), 3; 304-309

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Lovastatin; Preconcentration; Human serum; Hanging mercury drop electrode

Sažetak
Adsorption and reduction of lovastatin were investigated by cyclic and square-wave voltammetry on a hanging mercury drop electrode in aqueous solutions over a wide pH range (4-9). The electroreduction of lovastatin proceeds via a surface EC mechanism in the whole pH range investigated. Using adsorptive stripping voltammetry, the drug yielded a well-defined voltammetric response in Britton-Robinson buffer, pH 6 at -1.49 V which can be used to determine trace amount of lovastatin. The linear concentration range of application was 1.0 × 10-8 – 1.0 × 10-7 M by using an accumulation potential of -0.5 V and a 90 s pre-concentration time. The method has been successfully applied for the determination of lovastatin in a spiked human serum sample.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA