Naslov
Influence of toxic and essential metals on markers of atopy and ventilatory function in men and women

Autori
Pizent, Alica ; Macan, Jelena ; Jurasović, Jasna ; Varnai, Veda Marija ; Kanceljak-Macan, Božica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts for a conference on trace elements in diet, nutrition, and health: essentiality and toxicity. Cell Biol Toxicol 24 (Suppl 1) / Nordberg, Monica - : Springer, 2008

Skup
ISTERH-NTES-HTES A Joint Conference on Trace Elements in Diet, Nutrition, and Health: Essentiality and Toxicity

Mjesto i datum
Hersonissos, Grčka, 21.10.2007. - 26.10.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Toxic and essential metals; anti-oxidant enzymes; atopy; ventilatory function; airway reactivity

Sažetak
The combined influence of age, smoking, alcohol, erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx) in whole blood, blood lead (BPb), and cadmium (BCd) levels, and serum levels of copper (SCu), zinc (SZn), and selenium (SSe) on atopic status and ventilatory function was examined in the groups of men and women with no occupational exposure to metals. Markers of atopy included serum total IgE, skin prick test (SPT) to common inhalatory allergens, nonspecific nasal reactivity (NR) and nonspecific bronchial reactivity (BR). Parameters of ventilatory function included forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), each expressed as percentage. A significantly (p<0.05) higher BPb, SZn, IgE, and incidence of positive SPT and lower SCu and NR was found in men than in women. In men, IgE inversely correlated with SSe (p<0.03), and FVC% and FEV1% inversely correlated with smoking intensity (p<0.0001 and p<0.005, respectively) and BCd (p<0.007 and p<0.005, respectively). In women, IgE positively correlated with BPb (p<0.02), and NR positively correlated with GPx (p<0.02). After adjusting for potentially confounding variables by multiple regression in the group of men, an increase in BR was associated with an increase in age (p<0.01) and a decrease in SSe (p<0.01) and log BPb (p<0.02) ; a decrease in FVC% was associated with an increase in smoking intensity (p<0.0002) and a decrease in SZn (p<0.05) ; a decrease in FEV1% was associated with an increase in smoking intensity (p<0.002) and SOD (p<0.05), and a decrease in SZn (p=0.05). In women, an increase in log IgE was associated with a decrease in SCu (p<0.05) ; an increase in NR was associated with an increase in GPx (p<0.02) and a decrease in SCu (p<0.05). The observed difference in response between the groups of men and women may partly be explained by different levels of relevant toxic and essential metals and particularly their combination.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

Napomena
DOI : 10.1007/s10565-007-9052-8 ; SpringerLink Date: Wednesday, January 16, 2008

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