Pregled bibliografske jedinice broj: 33129
Potentiation of levodopa induced efects in PD patients by pretreatment with antiglutamatergic drugs
Potentiation of levodopa induced efects in PD patients by pretreatment with antiglutamatergic drugs // Abstracts Society for Neuroscience / Levitt (ur.).
Washington (MD): Society for Neuroscience, 1998. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 33129 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Potentiation of levodopa induced efects in PD patients by pretreatment with antiglutamatergic drugs
Autori
Relja, Maja ; Šalkovic-Petrišić, Melita
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstracts Society for Neuroscience
/ Levitt - Washington (MD) : Society for Neuroscience, 1998
Skup
28th Annual Meeting Society for Neuroscience
Mjesto i datum
Sjedinjene Američke Države, 07.11.1998. - 12.11.1998
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
levodopa; antiglutamatergic drugs; PD
Sažetak
Increased glutamatergic transmission has been implicated in the pathophysiology of Parkinson's disease (PD). However, systemic injections of antiglutamatergic drugs have failed to produce significant amelioration of PD symptoms. This prompted us to investigate the possible involvement of glutamatergic mechanism in the dopaminergic response in PD patients. Using computerized device for quantifying rigidity from the elbow joint (Relja et al., Clin Neuropharmacol 1996;19:148), we have studied the rigidity response in idiopathic PD patients after acute challenge with dopaminomimetics (DA) and NMDA and non-NMDA glutamate (GLU) receptor antagonists. The investigation was conducted following the Declaration of Helsinki. Twenty idiopathic PD patients were included in the study, and informed consent was obtained. Rigidity measurement was performed in the morning before and 90 minutes after single oral administration of DA drugs (levodopa/DDI, bromocriptine), and/or antiglutamatergics (memantine, lamotrigine, riluzole). DA drugs significantly (p<0.001) decreased rigidity, while GLU antagonists had only a slight effect. However, when DA drugs were co-administered with GLU antagonists, the rigidity response of both drugs together was significantly additive (P<0.05). These results suggest that GLU can modify DA response, and that a combination therapy may be beneficial for PD patients.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
