Pregled bibliografske jedinice broj: 33089
Possible role of the Na/H exchanger in the generation of hypertension
Possible role of the Na/H exchanger in the generation of hypertension // Liječnički vjesnik, 118 (1996), Suppl 2; 46-49 (podatak o recenziji nije dostupan, članak, znanstveni)
CROSBI ID: 33089 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Possible role of the Na/H exchanger in the generation of hypertension
(Possible role in the Na/H exchanger in the generation of hypertesion)
Autori
Rosskopf, D. ; Coppola, S. ; Samaržija, Ita ; Siffert, W. ; Dusing, R. ; Fromter, E.
Izvornik
Liječnički vjesnik (1330-4917) 118
(1996), Suppl 2;
46-49
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
hypertension; carrier proteins; sodium; ion transport
Sažetak
The Na/H exchanger is a membrane protein that is expressed in virtually all mamalian cells. Genetically determined stimulation of this protein in salt-sensitive hypertension and type 1 diabetes with nephropathy may be responsible for the generation of hypertension either by elevating intracellular Na- and consequently Ca- concentrations and thereby increasing vascular smooth muscle tone or by stimulating proliferation in the sence of primary cardiovascular hypertrophy. The same may hold for chronic salt loading in which case the exchanger may be stimulated by a mild systemic acidosis that develops from increasing renal tubular HCO3-loss following the suppression of angiotensin II.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
