Naslov
Incidence of Down's syndrome in the municipality of Rijeka and Istrian region

Autori
Brajenović-Milić, Bojana, Ristić, Smiljana ; Kapović, Miljenko ; Mojsović, Anđelko ; Medica, Igor ; Modrušan-Mozetić, Zlata

Izvornik
Collegium antropologicum (0350-6134) 20 (1996), S1; 1-5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Down syndrome ; incidence

Sažetak
The aim of this work was to estimate the incidence of trisomy 21, the Down's syndrome, and the minimal rate of chromosome mutation in the municipality of Rijeka and in the Istrian region for the period 1986-1994. In the same period the Institute for Biology of the University of Rijeka School of Medicine has been carrying out prenatal diagnostics, and during this period only one case of DS has been established. However, 59 children with the same syndrome were born within this period. In view of that, we were also interested to find out whether this suggests disregard of negligence of existing indications for prenatal diagnostics, or otherwise the necessity of introducing prenatal screening tests. The incidence of trisomy 21 in the municipality of Rijeka was 1.66/1.000 new-born children, and the minimal rate of chromosome mutation was 8.3x10(-4). In the Istrian region the incidence was 1.51/1.000 with the minimal rate of chromosome mutation of 7.6x10(-4). The mean age of mothers of DS children was 29.4+/-6.7 years, and the paternal mean age was 31.9+/-6.9. The phenomenon of birth order and the Down syn drome indicate that a younger mother (<29) bears a DS child as the first or as the second - born child, and the older mother (>34) as the third, fourth or last born child. Out of 58 reported cases of DS, two mothers (3.4%) were of border age (34 years), and ten (17.2%) were over 35. Despite the fact that our sample was relatively small, and thus inappropriate for making conclusions, it should be pointed out that the number of very young mothers of children with DS was higher than expected and that it would be necessary to introduce and apply prenatal screening tests that could cover the entire population of pregnant women.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA