Naslov
Metallothioneins and tissue metals as regulators of cellular growth and proliferation

Autori
Milin, Čedomila ; Radošević-Stašić, Biserka

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni

Knjiga
Biochemistry and Immunology Intersections

Urednik/ci
Markotić, Anita ; Glavaš-Obrovac, Ljubica ; Varljen, Jadranka ; Žanić-Grubišić, Tihana

Izdavač
Research Signpost

Grad
Lahti

Godina
2008

Raspon stranica
173-184

ISBN
978-81-308-0265-7

Ključne riječi
Metallothioneins, metals, liver regeneration

Sažetak
Metallothioneins (MT) are a family of ubiquitous, intracellular, low molecular cysteine-rich heavy metal binding proteins, whose precise biological function is still investigating. Their expression may be driven through several response elements in the MT gene promoter: 1) metal response elements (MRE), which are activated by the metal-responsive transcription factor-1 (MTF-1) after zinc occupancy, 2) glucocorticoid responsive elements (GRE) ; 3) elements activated by signal transducers and activators of transcription (STAT) proteins through cytokine signaling and 4) the antioxidant (or electrophile) response element (ARE)activated in response to redox status. Owing to this, MTs have been considered to be a stress or acute phase proteins, whose induction dramatically increases in response to tissue injury, infection, inflammation and neoplastic disease. It is however, of particular interest that both nuclear and cytoplasmic localization of MTs might be transiently expressed also during fetal development and in several growing tissues, implying that they might participate in DNA synthesis-and apoptosis-related processes, in regulation of transition from proliferation to the differentiation stage, as well as in several immune-related processes that initiate and coordinate the normal growth. In an attempt to underline the physiological functions of MTs we will briefly review the data pointing to the dynamic link between the metallothionein expression and tissue metal kinetics in the liver and in the lymphatic tissue during the fast liver growth, induced by partial hepatectomy.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA