Pregled bibliografske jedinice broj: 329888
Expression of bacteriophage derived scFv and their incorporation into third generation porphyrin immunoconjugates for targeted PDT
Expression of bacteriophage derived scFv and their incorporation into third generation porphyrin immunoconjugates for targeted PDT // 10th World Congress of the International Photodynamic Association
München, Njemačka, 2005. (poster, nije recenziran, neobjavljeni rad, znanstveni)
CROSBI ID: 329888 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Expression of bacteriophage derived scFv and their incorporation into third generation porphyrin immunoconjugates for targeted PDT
Autori
Staneloudi, Chrysovalanto ; Smith, Karen A. ; Hudson, Robert ; Pesa, Nela ; Savoie, Huguettte ; Boyle, Ross W. ; Greenman, John
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni
Skup
10th World Congress of the International Photodynamic Association
Mjesto i datum
München, Njemačka, 22.06.2005. - 25.06.2005
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
Photodynamic therapy; scFv; Phage display; Porphyrin; Bioconjugation
Sažetak
An expression system giving high yield of scFv fragments has been established. The molar ratios at which the conjugation to scFv was carried out has been optimized. These immunoconjugates showed low levels of non-covalently associated porphyrin, minimizing potential non-specific cytotoxicity. Based on these findings, together with preliminary data using immunoconjugates of scFv raised against freshly-isolated tumour cells, we suggest that scFv:poprhyrin conjugates may show promise for use as an antibody-targeted photodynamic strategy.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti
