Pregled bibliografske jedinice broj: 329868
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers // Book of Abstracts
Aix-les-Bains, Francuska, 2005. (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 329868 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers
Autori
Peša, Nela ; Smith, Karen A. ; Savoie, Huguette ; Greenman, John ; Boyle, Ross W.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Book of Abstracts
/ - , 2005
Skup
11th Congress of the European Society for Photobiology (ESP)
Mjesto i datum
Aix-les-Bains, Francuska, 03.09.2005. - 08.09.2005
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
Photodynamic therapy; Porphyrin; Monoclonal antibodies; Bioconjugation
Sažetak
Four cationic isothiocyanato diphenyl and one tetraphenyl porphyrins were synthesised. Their bioconjugation to several Mabs was successfully carried out without compromising the binding of the antibodies. Cytotoxicity assays and the LD50’ s show that the porphyrin conjugates were more photocytotoxic than free porphyrin. Porphyrin 4 caused cell death through the rapid onset of apoptosis probably due to its mitochondrial localisation.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti
