Pregled bibliografske jedinice broj: 329499
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers // International Journal of Oncology, 28 (2006), 6; 1561-1569 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 329499 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis and in vitro investigation of cationic 5, 15-diphenyl porphyrin-monoclonal antibody conjugates as targeted photodynamic sensitisers
Autori
Malatesti, Nela ; Smith, Karen ; Savoie, Huguette ; Greenman, John ; Boyle, Ross W.
Izvornik
International Journal of Oncology (1019-6439) 28
(2006), 6;
1561-1569
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Photodynamic therapy; Monoclonal antibodies; Porphyrins
Sažetak
The synthesis of three cationic 5, 15-diphenyl porphyrins, bearing an isothiocyanate group for conjugation to proteins is described. The potential of these compounds as targeted photosensitisers for use in photodynamic therapy (PDT) is demonstrated by their efficient conjugation to monoclonal antibodies and the ability of the bioconjugates to bind and photodynamically inactivate cancer cells that express the corresponding antigen.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- BIOSIS Previews (Biological Abstracts)
- CA Search (Chemical Abstracts)
- MEDLINE
- Scisearch
- Cambridge Scientific Abstracts
- Current Awareness in Biological Sciences
