Naslov
Autologous bone marrow and/or peripheral blood stem cells transplantation in patients with poor risk malignant lymphoma

Autori
Minigo, Hrvoje ; Planinc-Peraica, Ana ; Kardum-Skelin, Ika ; Šušterčić, Dunja ; Ostojić, Slobodanka ; Radić-Krišto, Delfa ; Šiftar, Zoran ; Strauss-Patko, Maja ; Maglov, Čedomir ; Jakšić, Branimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Bone Marrow Transplantation / - , 1998

Skup
25th Annual Meeting European Group for Blood and Marrow Transplantation and 15th Meeting of the Nourses Group

Mjesto i datum
Courmayeur, Italija, 22.03.1988. - 26.03.1988

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Autologous stem cell transplantation; malignant lymphomas

Sažetak
From Nov. 93. to Nov. 97., 42 heavily pretreated patients with poor risk malignant lymphoma (18 with HD and 24 with NHL, median age 31, range 18-57, FM 16/26) were treated with BEAM myeloablative chemotherapy, followed by ABMT and/or PBSCT and growth factor support. Only 2 patients were transplanted in CR, and all others had active disease. 13 patients were transplanted with autologous BM only. 17 with autologous BM+PBSC, and 12 with PBSC only. Mean of CD34+ cells transplanted was 2, 99 *106/kg BW. 41 patients were after transplantation supported with G-CSF (5 mcg/kg/d during the period of leukopenia less then 1.0 ; median duration 10 days /range 6-20/). Number of febrile days in pancytopenic period was 4 days (range 0-15). Patients were supported with 16 doses of platelet concentrates (range 6-46) and a median of 630 ml RBC concentrates (range 0-1460). Seventeen patients did not require RBC support. Median time to WBC recovery to more then 1.0*109/L was 11 days (range 6-20) and to platelets recovery to more then 20*109/L was 14 days (range 6-30). CR was obtained in 24 (60%), and PR in 13(32%), out of 40 patients with active disease. Transplant related mortality was 4, 67% (2/42). Projected survival from ABMT was 68% at 4 years, projected DFS was 72% at 4 years. HD patients had significantly better DFS then NHL patients (p = 0.045). Cox analysis showed at a significant level an independent influence on DFS of age (p = 0.0397) and diagnosis (HD vs. NHL (p = 0.0481). We conclude that the performed procedure is safe, highly efficient for remission re-induction also in heavily pretreated patients, with durable responses and prolonged survival.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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