Naslov
Radiation-induced apoptosis of oligodendrocytes in vitro

Autori
Vrdoljak, Eduard ; Bill, C. A. ; Stephens, L. C. ; van der Kogel, A. J. ; Ang, K. K. ; Tofilon, P. J.

Izvornik
International journal of radiation biology (0955-3002) 62 (1992), 4; 475-480

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
radiation demage ; oligodenrocytes ; demyelination ; apoptosis

Sažetak
It has been suggested that glial cells and/or their progenitors are the primary target cells for radiation-induced demyelination. Cultures of terminally differentiated oligodendrocytes, immature oligodendrocytes, and O-2A progenitor cells were generated from the cerebral cortex and spinal cord of perinatal rat pups. Irradiation of cultures of terminally differentiated oligodendrocytes resulted in a significant increase in the percentage of apoptotic cells from 15% in control to 30% in irradiated samples, with the maximum increase induced by 10 Gy. This increase in apoptosis could be observed by 1 h after irradiation with the maximum level reached at 3-6 h. Apoptotic cells were not detected before or after irradiation of cultures of O-2A progenitor cells or immature oligodendrocytes. These data suggest that radiation-induced apoptosis of terminally differentiated oligodendrocytes may be involved in early demyelination.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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