Change in transferrin sialylation is a potential prognostic marker for severity of acute pancreatitis

Gornik, Olga; Gornik, Ivan; Gašparović, Vladimir; Lauc, Gordan

doi:10.1016/j.clinbiochem.2008.01.026

Pregled bibliografske jedinice broj: 326886

Change in transferrin sialylation is a potential prognostic marker for severity of acute pancreatitis

Gornik, Olga; Gornik, Ivan; Gašparović, Vladimir; Lauc, Gordan

Change in transferrin sialylation is a potential prognostic marker for severity of acute pancreatitis // Clinical Biochemistry, 41 (2008), 7-8; 504-510 doi:10.1016/j.clinbiochem.2008.01.026 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 326886 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Change in transferrin sialylation is a potential prognostic marker for severity of acute pancreatitis

Autori
Gornik, Olga ; Gornik, Ivan ; Gašparović, Vladimir ; Lauc, Gordan

Izvornik
Clinical Biochemistry (0009-9120) 41 (2008), 7-8; 504-510

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acute pancreatitis; sialylation; transferrin; glycosylation; serum proteins; prognostic marker

Sažetak
Early prediction of severe acute pancreatitis is one of the problems in clinical practice. Since many diseases are associated with alteration in glycosylation, in this work we studied sialylation of transferrin and serum proteins in acute pancreatitis. Sialylation was analyzed during first eight days of hospitalization of 30 patients and compared to 30 healthy controls. Transferrin sialylation was measured using enzyme linked lectin assay, while sialic acid on proteins was measured using resorcinol method. Both analyzed parameters changed during studied period. The change in transferrin sialylation between Day1 and Day2 of hospitalization was shown to be early prognostic marker of acute pancreatitis, with better sensitivity (88.9%) and specificity (90.5%) than other markers tested. Sialylation of transferrin and total serum proteins reflects the intensity of inflammatory response during acute pancreatitis and could be used as prognostic parameter for disease severity.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA

Projekti:
309-0061194-2023 - Glikoproteomika stresa i bolesti povezanih sa stresom
006-0061194-1218 - Glikobiološki aspekti stanične prilagodbe i komunikacije (Dumić, Jerka, MZOS ) ( CroRIS)
108-0000000-0180 - Utjecaj dvije strategije liječenja na preživljavanje u sepsi, MODS-u i MOF-u (Gašparović, Vladimir, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Osijek

Profili:

Olga Gornik Kljaić (autor)