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Pregled bibliografske jedinice broj: 326803

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

Vitart, Veronique; Rudan, Igor; Hayward, Caroline; Gray, Nicola K.; Floyd, James; Palmer, Colin N. A.; Knott, Sara A.; Kolcic, Ivana; Polašek, Ozren; Graessler, Juergen et al.
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout // Nature Genetics, 40 (2008), 4; 437-442 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 326803 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

Autori
Vitart, Veronique ; Rudan, Igor ; Hayward, Caroline ; Gray, Nicola K. ; Floyd, James ; Palmer, Colin N. A. ; Knott, Sara A. ; Kolcic, Ivana ; Polašek, Ozren ; Graessler, Juergen ; Wilson, James F. ; Marinaki, Anthony ; Riches, Philip L. ; Shu, Xinhua ; Janićijević, Branka ; Smolej-Narančić, Nina ; Gorgoni, Barbara ; Morgan, Joanne ; Campbell, Susan ; Biloglav, Zrinka ; Barać-Lauc, Lovorka ; Peričić, Marijana ; Martinović-Klarić, Irena ; Zgaga, Lina ; Škarić-Jurić, Tatjana ; Wild, Sarah H. ; Richardson, William A. ; Hohenstein, Peter ; Kimber, Charley K. ; Tenesa, Albert ; Donnelly, Louise A. ; Fairbanks, Lynette D. ; Aringer, Martin ; McKeigue, Paul M. ; Ralston, Stuart H. ; Morris, Andrew D. ; Rudan, Pavao ; Hastie, Nicholas D. ; Campbell, Harry ; Wright, Alan F.

Izvornik
Nature Genetics (1061-4036) 40 (2008), 4; 437-442

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
SLC2A9 gene; uric acid; urate excretion; gout; genome-wide association study

Sažetak
Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200?500 lM) compared with other mammals (3?120 lM)1. About 70% of daily urate disposal occurs via the kidneys, and in 5?25% of the human population, impaired renal excretion leads to hyperuricemia2. About 10% of people with hyperuricemia develop gout, an inflammatory arthritis that results from deposition of monosodium urate crystals in the joint. We have identified genetic variants within a transporter gene, SLC2A9, that explain 1.7?5.3% of the variance in serum uric acid concentrations, following a genome-wide association scan in a Croatian population sample. SLC2A9 variants were also associated with low fractional excretion of uric acid and/or gout in UK, Croatian and German population samples. SLC2A9 is a known fructose transporter3, and we now show that it has strong uric acid transport activity in Xenopus laevis oocytes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija



POVEZANOST RADA

Projekti:
196-1962766-2747 - Kompleksna obilježja i zdravlje stanovništva od djetinjstva do duboke starosti (Smolej-Narančić, Nina, MZOS ) ( CroRIS)
196-1962766-2751 - Populacijska struktura Hrvatske - antropogenetički pristup (Rudan, Pavao, MZOS ) ( CroRIS)
196-1962766-2763 - Molekularno-genetička obilježja populacija utemeljitelja - Romi kao model (Janićijević, Branka, MZOS ) ( CroRIS)
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Institut za antropologiju,
Medicinski fakultet, Split

Profili:

Avatar Url Irena Martinović Klarić (autor)

Avatar Url Lovorka Barać Lauc (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Igor Rudan (autor)

Avatar Url Marijana Peričić Salihović (autor)

Avatar Url Ivana Kolčić (autor)

Avatar Url Tatjana Škarić-Jurić (autor)

Avatar Url Branka Janićijević (autor)

Avatar Url Pavao Rudan (autor)

Avatar Url Zrinka Biloglav (autor)

Avatar Url Lina Zgaga (autor)

Avatar Url Nina Smolej-Narančić (autor)

www.nature.com

Citiraj ovu publikaciju:

Vitart, Veronique; Rudan, Igor; Hayward, Caroline; Gray, Nicola K.; Floyd, James; Palmer, Colin N. A.; Knott, Sara A.; Kolcic, Ivana; Polašek, Ozren; Graessler, Juergen et al.
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout // Nature Genetics, 40 (2008), 4; 437-442 (međunarodna recenzija, članak, znanstveni)
Vitart, V., Rudan, I., Hayward, C., Gray, N., Floyd, J., Palmer, C., Knott, S., Kolcic, I., Polašek, O. & Graessler, J. (2008) SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nature Genetics, 40 (4), 437-442.
@article{article, author = {Vitart, Veronique and Rudan, Igor and Hayward, Caroline and Gray, Nicola K. and Floyd, James and Palmer, Colin N. A. and Knott, Sara A. and Kolcic, Ivana and Pola\v{s}ek, Ozren and Graessler, Juergen and Wilson, James F. and Marinaki, Anthony and Riches, Philip L. and Shu, Xinhua and Jani\'{c}ijevi\'{c}, Branka and Smolej-Naran\v{c}i\'{c}, Nina and Gorgoni, Barbara and Morgan, Joanne and Campbell, Susan and Biloglav, Zrinka and Bara\'{c}-Lauc, Lovorka and Peri\v{c}i\'{c}, Marijana and Martinovi\'{c}-Klari\'{c}, Irena and Zgaga, Lina and \v{S}kari\'{c}-Juri\'{c}, Tatjana and Wild, Sarah H. and Richardson, William A. and Hohenstein, Peter and Kimber, Charley K. and Tenesa, Albert and Donnelly, Louise A. and Fairbanks, Lynette D. and Aringer, Martin and McKeigue, Paul M. and Ralston, Stuart H. and Morris, Andrew D. and Rudan, Pavao and Hastie, Nicholas D. and Campbell, Harry and Wright, Alan F.}, year = {2008}, pages = {437-442}, keywords = {SLC2A9 gene, uric acid, urate excretion, gout, genome-wide association study}, journal = {Nature Genetics}, volume = {40}, number = {4}, issn = {1061-4036}, title = {SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout}, keyword = {SLC2A9 gene, uric acid, urate excretion, gout, genome-wide association study} }
@article{article, author = {Vitart, Veronique and Rudan, Igor and Hayward, Caroline and Gray, Nicola K. and Floyd, James and Palmer, Colin N. A. and Knott, Sara A. and Kolcic, Ivana and Pola\v{s}ek, Ozren and Graessler, Juergen and Wilson, James F. and Marinaki, Anthony and Riches, Philip L. and Shu, Xinhua and Jani\'{c}ijevi\'{c}, Branka and Smolej-Naran\v{c}i\'{c}, Nina and Gorgoni, Barbara and Morgan, Joanne and Campbell, Susan and Biloglav, Zrinka and Bara\'{c}-Lauc, Lovorka and Peri\v{c}i\'{c}, Marijana and Martinovi\'{c}-Klari\'{c}, Irena and Zgaga, Lina and \v{S}kari\'{c}-Juri\'{c}, Tatjana and Wild, Sarah H. and Richardson, William A. and Hohenstein, Peter and Kimber, Charley K. and Tenesa, Albert and Donnelly, Louise A. and Fairbanks, Lynette D. and Aringer, Martin and McKeigue, Paul M. and Ralston, Stuart H. and Morris, Andrew D. and Rudan, Pavao and Hastie, Nicholas D. and Campbell, Harry and Wright, Alan F.}, year = {2008}, pages = {437-442}, keywords = {SLC2A9 gene, uric acid, urate excretion, gout, genome-wide association study}, journal = {Nature Genetics}, volume = {40}, number = {4}, issn = {1061-4036}, title = {SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout}, keyword = {SLC2A9 gene, uric acid, urate excretion, gout, genome-wide association study} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • Biological Sciences
  • EMBASE (Excerpta Medica)
  • Human Genome Abstracts
  • MEDLINE

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