Naslov
Sinteza i struktura biokonjugata ferocenskih diamina i aminokiselina
(Synthesis and structure of boconjugates containing ferrocene diamines and amino acids subunits)

Autori
Đaković, Senka ; Rapić, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XX. Jubilarni hrvatski skup kemičara i kemijskih inženjera, Knjiga sažetaka / Vasić-Rački, Đurđa - Zagreb : Petrokemija Kutina, 2007, 56-56

ISBN
978-953-6894-29-1

Skup
XX. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 26.02.2007. - 01.03.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
ferocenski diamini; biokonjugati; aminokiseline; sinteza
(ferrocene diamines; bioconjugates; amino acids; synthesis)

Sažetak
A number of conjugates of ferrocene-1, 1’ -dicarboxylic acid with natural amino acids – Fn(COAA1-2OMe)2 have been prepared and investigated so far [1]. Our research group synthesized a various bioorganometallics composed from 1’ -amino-1-carboxylic acid and natural amino acids, aiming to investigate the role of ferrocene subunit as turn inducer and to study the intramolecular hydrogen bonds formed [2]. Symmetrically disubstituted bioconjugates of ferrocene-1, 1’ -diamine (Fcd) – Fn(NHAA1-2Boc)2 are described in solely one paper [3]. We directed our research to unsymmetrically substituted bioconjugates of Fcd (1) and compounds 2 containing the chiral center incorporated in the aliphatic part of molecule. Ferrocene diamines 1a and 2a were synthesized by multistep reactions using mostly the transformations similar to previously described [2]. Compounds 1b and 2b were prepared by reactions of 1a or 2a with Boc-protected natural amino acids using EDC/ HOBt protocol. Conformational analysis of the compounds prepared on the basis of IR, NMR-vr-, and CD-spectroscopy will be presented.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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