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Pregled bibliografske jedinice broj: 325795

The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations

Wittine, Karlo; Benci, Krešimir; Rajić, Zrinka; Zorc, Branka; Kralj, Marijeta; Marjanović, Marko; Pavelić, Krešimir; De Clercq, Eric; Andrei, Graciela; Snoeck, Robert et al.
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations // European journal of medicinal chemistry, 44 (2009), 1; 143-151 doi:10.1016/j.ejmech.2008.03.037 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 325795 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations

Autori
Wittine, Karlo ; Benci, Krešimir ; Rajić, Zrinka ; Zorc, Branka ; Kralj, Marijeta ; Marjanović, Marko ; Pavelić, Krešimir ; De Clercq, Eric ; Andrei, Graciela ; Snoeck, Robert ; Balzarini, Jan ; Mintas, Mladen

Izvornik
European journal of medicinal chemistry (0223-5234) 44 (2009), 1; 143-151

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Nonsteroidal Anti-Inflammatory Drugs (NSAID) ; 3-Hydroxypropylamides ; Phosphoramidates ; Cytostatic Activity

Sažetak
The target phosphoramidates 5a-e were prepared in one step from 3-hydroxypropyl derivatives 3a-e of nonsteroidal anti-inflammatory drugs (fenoprofen, ketoprofen, ibuprofen, indomethacin, diclofenac). The products 3a-e and 5a-e were evaluated for their cytostatic and antiviral activity against malignant tumour cell lines and normal human fibroblasts (WI38). All phosphoramidate derivatives 5a-e possess significantly greater inhibitory activities than the corresponding 3-hydroxypropyl derivatives 3a-e, whereby compound 5a showed the most potent inhibitory activities against cervical, pancreatic and colon carcinoma cell lines (IC50 = 5 7  M).

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA

Projekti:
098-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Kralj, Marijeta, MZOS ) ( CroRIS)
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Zorc, Branka, MZOS ) ( CroRIS)
125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mintas, Mladen, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Marko Marjanović (autor)

Avatar Url Branka Zorc (autor)

Avatar Url Mladen Mintas (autor)

Avatar Url Zrinka Rajić (autor)

Avatar Url Krešimir Benci (autor)

Avatar Url Krešimir Pavelić (autor)

Avatar Url Karlo Wittine (autor)

Avatar Url Marijeta Kralj (autor)

Poveznice na cjeloviti tekst rada:

doi dx.doi.org www.sciencedirect.com

Citiraj ovu publikaciju:

Wittine, Karlo; Benci, Krešimir; Rajić, Zrinka; Zorc, Branka; Kralj, Marijeta; Marjanović, Marko; Pavelić, Krešimir; De Clercq, Eric; Andrei, Graciela; Snoeck, Robert et al.
The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations // European journal of medicinal chemistry, 44 (2009), 1; 143-151 doi:10.1016/j.ejmech.2008.03.037 (međunarodna recenzija, članak, znanstveni)
Wittine, K., Benci, K., Rajić, Z., Zorc, B., Kralj, M., Marjanović, M., Pavelić, K., De Clercq, E., Andrei, G. & Snoeck, R. (2009) The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations. European journal of medicinal chemistry, 44 (1), 143-151 doi:10.1016/j.ejmech.2008.03.037.
@article{article, author = {Wittine, Karlo and Benci, Kre\v{s}imir and Raji\'{c}, Zrinka and Zorc, Branka and Kralj, Marijeta and Marjanovi\'{c}, Marko and Paveli\'{c}, Kre\v{s}imir and De Clercq, Eric and Andrei, Graciela and Snoeck, Robert and Balzarini, Jan and Mintas, Mladen}, year = {2009}, pages = {143-151}, DOI = {10.1016/j.ejmech.2008.03.037}, keywords = {Nonsteroidal Anti-Inflammatory Drugs (NSAID), 3-Hydroxypropylamides, Phosphoramidates, Cytostatic Activity}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2008.03.037}, volume = {44}, number = {1}, issn = {0223-5234}, title = {The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations}, keyword = {Nonsteroidal Anti-Inflammatory Drugs (NSAID), 3-Hydroxypropylamides, Phosphoramidates, Cytostatic Activity} }
@article{article, author = {Wittine, Karlo and Benci, Kre\v{s}imir and Raji\'{c}, Zrinka and Zorc, Branka and Kralj, Marijeta and Marjanovi\'{c}, Marko and Paveli\'{c}, Kre\v{s}imir and De Clercq, Eric and Andrei, Graciela and Snoeck, Robert and Balzarini, Jan and Mintas, Mladen}, year = {2009}, pages = {143-151}, DOI = {10.1016/j.ejmech.2008.03.037}, keywords = {Nonsteroidal Anti-Inflammatory Drugs (NSAID), 3-Hydroxypropylamides, Phosphoramidates, Cytostatic Activity}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2008.03.037}, volume = {44}, number = {1}, issn = {0223-5234}, title = {The novel phosphoramidate derivatives of NSAID 3-hydroxypropylamides: synthesis, cytostatic and antiviral activity evaluations}, keyword = {Nonsteroidal Anti-Inflammatory Drugs (NSAID), 3-Hydroxypropylamides, Phosphoramidates, Cytostatic Activity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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