Naslov
Degradation behavior of the hydrogel poly(vinyl alcohol)-graft-poly[(rac-lactide)-co-glycolide] under different conditions

Autori
Vidović, Elvira ; Klee, Doris ; Höcker Hartwig

Izvornik
Macromolecular symposia (1022-1360) 277 (2008), 1; 39-44

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aliphatic polyesters ; biomaterials ; degradation ; hydrogels ; hydrophilic polymers

Sažetak
The hydrogel poly(vinyl alcohol)-graft-poly[(rac-lactide)-co-glycolide)] [PVA-g-P(LGA)], containing nine ester groups in the polyester grafts (lactide:glycolide ratio 50:50) grafted onto PVA to an extent of 13%, and crosslinked via terminal acrylate groups was subjected to degradation experiments in phosphate buffer solution (pH 7.4) at room temperature and at 37 oC during 8 weeks. In the course of degradation, the properties of the hydrogel change as a result of the decrease of the polyester content. The increased temperature has a significant influence on the degradation rate but its amount varies with the methods applied. Thus, a large drop of the elastic modulus takes place in samples degraded at 37 oC with time and relative to RT. Thermal and IR analysis show changes while the initial difference between two sets of samples in contact angle is reduced with time.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo

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