Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 325247

Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity

Đilović, Ivica; Rubčić, Mirta; Vrdoljak, Višnja; Kraljević Pavelić, Sandra; Kralj, Marijeta; Piantanida, Ivo; Cindrić, Marina
Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity // Bioorganic & medicinal chemistry letters, 16 (2008), 9; 5189-5198 doi:10.1016/j.bmc.2008.03.006 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 325247 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity

Autori
Đilović, Ivica ; Rubčić, Mirta ; Vrdoljak, Višnja ; Kraljević Pavelić, Sandra ; Kralj, Marijeta ; Piantanida, Ivo ; Cindrić, Marina

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 16 (2008), 9; 5189-5198

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
thiosemicarbazone ; antitumor evaluation ; UV/vis spectroscopy ; DNA binding

Sažetak
The paper describes synthesis of several novel thiosemicarbazone derivatives. Furthermore, crystal and molecular structure of 4-diethylamino-salicylaldehyde 4- phenylthiosemicarbazone revealed planarity of conjugated aromatic system, which suggested the possibility of DNA binding by intercalation, especially for here studied naphthalene derivatives. However, here presented DNA binding studies excluded this mode of action. Physicochemical and structural properties of novel derivatives were compared with previously studied analogues, taken as reference compounds, revealing distinctive differences. In addition, novel thiosemicarbazone derivatives (1, 2 and 5-8) clearly display stronger antiproliferative activity on five tumor cell lines than the reference compounds 3 and 4, which supports their further investigation as potential antitumor agents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Kralj, Marijeta, MZOS ) ( CroRIS)
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Piantanida, Ivo, MZOS ) ( CroRIS)
119-1191342-1082 - Novi kompleksni spojevi i materijali-kemijski i biološki katalizatori (Cindrić, Marina, MZOS ) ( CroRIS)
119-1193079-1084 - Strukturno istraživanje bioloških makromolekula metodom rentgenske difrakcije (Matković-Čalogović, Dubravka, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Ivo Piantanida (autor)

Avatar Url Sandra Kraljević Pavelić (autor)

Avatar Url Višnja Vrdoljak (autor)

Avatar Url Marijeta Kralj (autor)

Avatar Url Ivica Đilović (autor)

Avatar Url Marina Cindrić (autor)

Avatar Url Mirta Rubčić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Đilović, Ivica; Rubčić, Mirta; Vrdoljak, Višnja; Kraljević Pavelić, Sandra; Kralj, Marijeta; Piantanida, Ivo; Cindrić, Marina
Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity // Bioorganic & medicinal chemistry letters, 16 (2008), 9; 5189-5198 doi:10.1016/j.bmc.2008.03.006 (međunarodna recenzija, članak, znanstveni)
Đilović, I., Rubčić, M., Vrdoljak, V., Kraljević Pavelić, S., Kralj, M., Piantanida, I. & Cindrić, M. (2008) Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity. Bioorganic & medicinal chemistry letters, 16 (9), 5189-5198 doi:10.1016/j.bmc.2008.03.006.
@article{article, author = {\DJilovi\'{c}, Ivica and Rub\v{c}i\'{c}, Mirta and Vrdoljak, Vi\v{s}nja and Kraljevi\'{c} Paveli\'{c}, Sandra and Kralj, Marijeta and Piantanida, Ivo and Cindri\'{c}, Marina}, year = {2008}, pages = {5189-5198}, DOI = {10.1016/j.bmc.2008.03.006}, keywords = {thiosemicarbazone, antitumor evaluation, UV/vis spectroscopy, DNA binding}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmc.2008.03.006}, volume = {16}, number = {9}, issn = {0960-894X}, title = {Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity}, keyword = {thiosemicarbazone, antitumor evaluation, UV/vis spectroscopy, DNA binding} }
@article{article, author = {\DJilovi\'{c}, Ivica and Rub\v{c}i\'{c}, Mirta and Vrdoljak, Vi\v{s}nja and Kraljevi\'{c} Paveli\'{c}, Sandra and Kralj, Marijeta and Piantanida, Ivo and Cindri\'{c}, Marina}, year = {2008}, pages = {5189-5198}, DOI = {10.1016/j.bmc.2008.03.006}, keywords = {thiosemicarbazone, antitumor evaluation, UV/vis spectroscopy, DNA binding}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmc.2008.03.006}, volume = {16}, number = {9}, issn = {0960-894X}, title = {Novel thiosemicarbazone derivatives as potential antitumor agents: synthesis, physico-chemical and structural properties, DNA interactions and antiproliferative activity}, keyword = {thiosemicarbazone, antitumor evaluation, UV/vis spectroscopy, DNA binding} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.