Naslov
Tumor Necrosis Factor-Alpha in Peripical Tissue Exudates of Teeth with Apical Periodontitis

Autori
Pezelj-Ribarić, Sonja ; Magašić, Karolina ; Prpić, Jelena ; Miletić, Ivana ; Karlović, Zoran

Izvornik
Mediators of Inflammation (0962-9351) 2007 (2007), 69416; 1-4

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
tumor necrosis factor-alpha; periapical exudates

Sažetak
Aim. The aim of this study was to determine tumor necrosis factor-alpha (TNF-&#945; ) levels in periapical exudates and to evaluate their relationship with radiological findings. Methodology. Periapical exudates were collected from root canals of 60 single-rooted teeth using absorbent paper points. TNF-&#945; levels were determined by enzyme-linked immunosorbent assays. The samples were divided into three groups according to the periapical radiolucent area. Results. Nonparametric Kruskal-Wallis test revealed significant differences between TNF-&#945; concentrations in control group (40, 57&plusmn ; ; ; ; ; ; 28, 15 pg/mL) and group with larger radiolucent areas (2365, 79&plusmn ; ; ; ; ; ; 582, 95 pg/mL), as well as between control and canals with small radiolucent areas (507, 66&plusmn ; ; ; ; ; ; 278, 97) (P<.05). Conclusions. The levels of TNF-&#945; increase significantly in teeth with periapical pathosis, from smaller to bigger lesions. This research and its results have shown that objective analysis of the TNF-&#945; levels enables establishment of a relationship between different concentrations of TNF-&#945; and different radiological changes.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA