Naslov
Changes of the Corpus Callosum in Children who Suffered Perinatal Injury of the Periventricular Crossroads of Pathways

Autori
Benjak, Vesna ; Čuljat, Marko ; Pavlović, Maja ; Kostović Srzentić, Mirna

Izvornik
Collegium Antroplogicum (0350-6134) 32 (2008), 1; 25-29

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
human; development; periventricular crossroads; corpus callosum; magnetic resonance; ultrasound

Sažetak
There is a high incidence of periventricular leukomalacia, caused by hypoxia-ischemia, in preterm infants. These lesions damage the periventricular crossroads of commissural, projection and associative pathways, which are in a close topographical relationship with the lateral ventricles. We explored to what extent abnormalities of echogenicity of the periventricular crossroads of pathways correlate with changes of commissural fibers of the corpus callosum. Our study included nine children (gestation from 26-41 ; birth weight between 938-4450 grams) with perinatal brain injury. Periventricular areas, which topographically correspond to the frontal, main and occipital crossroad of pathways, were readily visualized by cranial ultrasound scans, performed during the first two weeks after birth. Corpus callosum mediosagittal area measurements were performed using magnetic resonance images, acquired between the first and sixth postnatal month (postmenstrual age 40-49 weeks). We found a statistically significant correlation between the increased echogenicity in the crossroad areas and the decrease of the corpus callosum midsagittal area (p<0.05). This supports the hypothesis that callosal fibers can be damaged, during growth through the periventricular crossroads of pathways.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA