The effect of lamotrigine on platelet monoamine oxidase type B activity in patients with bipolar depression

Muck-Šeler, Dorotea; Šagud, Marina; Mustapić, Maja; Nedić, Gordana; Babić, Ana; Mihaljević Peleš, Alma; Jakovljević, Miro; Pivac, Nela

doi:10.1016/j.pnpbp.2008.03.004

Pregled bibliografske jedinice broj: 324564

The effect of lamotrigine on platelet monoamine oxidase type B activity in patients with bipolar depression

Muck-Šeler, Dorotea; Šagud, Marina; Mustapić, Maja; Nedić, Gordana; Babić, Ana; Mihaljević Peleš, Alma; Jakovljević, Miro; Pivac, Nela

The effect of lamotrigine on platelet monoamine oxidase type B activity in patients with bipolar depression // Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32 (2008), 5; 1195-1198 doi:10.1016/j.pnpbp.2008.03.004 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 324564 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The effect of lamotrigine on platelet monoamine oxidase type B activity in patients with bipolar depression

Autori
Muck-Šeler, Dorotea ; Šagud, Marina ; Mustapić, Maja ; Nedić, Gordana ; Babić, Ana ; Mihaljević Peleš, Alma ; Jakovljević, Miro ; Pivac, Nela

Izvornik
Progress in Neuro-Psychopharmacology and Biological Psychiatry (0278-5846) 32 (2008), 5; 1195-1198

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bipolar disorder ; depressive phase ; lamotrigine ; platelet monoamine oxidase type B

Sažetak
Lamotrigine is an anticonvulsant drug effective in the treatment of epilepsy and bipolar depression. Preclinical data showed that lamotrigine inhibited monoamine oxidase (MAO) activity in vitro. The aim of the study was to determine the effects of 6-weeks lamotrigine treatment on platelet MAO type B (MAO-B) activity in patient with bipolar depression. The study included 26 female patients with bipolar I disorder in depressive episode (DSM-IV criteria, Hamilton Depression Rating Scale (HAMD) and Young Mania Rating Scale. Platelet MAO-B activity was determined spectrofluorimetrically before and after 6 weeks of the treatment with a relatively low dose of lamotrigine (100 mg/day). Six weeks of treatment with lamotrigine significantly decreased platelet MAO-B activity in bipolar depressed patients. This inhibitory effect was not related to smoking status and was independent of the treatment combinations (lamotrigine alone or in combination with either lithium or antipsychotics). Lamotrigine treatment induced a decrease in total HAMD scores in bipolar depressed patients, which was not significantly correlated with reduction of platelet MAO-B activity. These findings provide in vivo insight of lamotrigine effect on platelet MAO-B activity in patients with bipolar depression. Its in vivo MAO-B inhibiting effect might have contributed in part to its antidepressant activity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( CroRIS)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( CroRIS)
108-1083509-3513 - Farmakogenetska varijabilnost u psihijatrijskih bolesnika (Mihaljević-Peleš, Alma, MZOS ) ( CroRIS)
108-1080037-0323 - Multidimenzionalna analiza bioloških pokazatelja u duševnim poremećajima (Jakovljević, Miro, MZOS ) ( CroRIS)